Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE It is concluded that PTHrP has several distinct paracrine, autocrine, and intracrine actions in the course of breast cancer pathophysiology. 31087800

2019

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Furthermore, our own studies have recently shown the critical role of PTHrP in breast cancer initiation, growth, and metastasis. 31576548

2019

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Breast cancer (BCa) bone metastases (BMETs) drive osteolysis via a feed-forward loop involving tumoral secretion of osteolytic factors (e.g., PTHrP) induced by bone-matrix-derived growth factors (e.g., TGFβ). 30393127

2019

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Prolactin stimulated PTHrP transcript and protein in breast cancer cell lines <i>in vitro</i> and <i>in vivo</i>, effects mediated by Stat5 through the P2 gene promoter, producing transcript AT6 encoding the PTHrP 1-173 isoform. 30097435

2018

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Together, by controlling the expression of PTHrP and its downstream OPG/RANKL, TF-SB has significant inhibition effects on breast cancer bone metastasis, which indicates a new therapeutic method. 29512770

2018

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Parathyroid hormone-related protein (PTHrP) expression in breast cancer is enriched in bone metastases compared to primary tumors. 29867773

2018

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE We recently identified a unique peptide fragment of parathyroid hormone-related protein (PTHrP), PTHrP(12-48), as a validated serum biomarker in breast cancer patients that correlates with and predicts the presence of bone metastases. 28370412

2017

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Immunohistochemistry was used to examine PTHrP and TGF-β protein expression in 497 cases of early breast cancer, and Kaplan-Meier method and COX's Proportional Hazard Model were applied to the prognostic value of PTHrP and TGF-β expression. 26597083

2015

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Once formed, Smad2/3:Gli2 complexes stimulate the expression of parathyroid hormone-related protein necessary for breast cancer metastasis to bone. 26160166

2015

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Integrated molecular analysis of both the EO771/EO771.LMB and 67NR/4T1.2 pairs indicated that upregulation of matrix metalloproteinase-3 (MMP-3), parathyroid hormone-like hormone (Pthlh) and S100 calcium binding protein A8 (S100a8) and downregulation of the thrombospondin receptor (Cd36) might be causally involved in metastatic dissemination of breast cancer. 25633981

2015

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE The statistical analysis revealed that PTHRP- and KRT19-positive detections correlated with the diagnosis of breast cancer while the combined positive detections of PTHRP-plus-KRT19 correlated with the presence of distant metastasis, especially with bone metastasis. 25368276

2014

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Furthermore, pharmacological inhibition of Rho-ROCK effectively reduced PTHLH production and breast cancer bone metastasis in vitro and in vivo. 24590291

2014

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE DBP-MDA-MB-231-CM reduced osteoblasts to produce osteoprotegerin, an osteoclastogenesis inhibitor, while DBP mediated PTHrP up-regulation, increasing IL-8 secretion in MDA-MB-231 and contributing to breast cancer-mediated osteoclast differentiation and bone resorption. 25415928

2014

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Collectively, these studies suggest that targeting PTHrP expression in the tumor cells could be a potential therapeutic strategy for breast cancers, especially those with skeletal metastases. 23983616

2013

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 GeneticVariation BEFREE We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. 23544012

2013

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth. 22267197

2012

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE In human breast cancer cells 5-HT induced both PTHrP and the metastasis-associated transcription factor Runx2/Cbfa1. 22318950

2012

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Now, research into the basic biology of PTHrP has suggested previously unrecognized connections to a variety of disease states such as osteoporosis, osteoarthritis, and breast cancer and has highlighted how PTHrP itself might be used in therapy for osteoporosis and diabetes. 22745236

2012

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 GeneticVariation BEFREE First, a report in Nature Genetics identified the PTHrP locus as a new breast cancer susceptibility gene. 22546075

2012

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Two of these seven SNPs are in linkage disequilibrium (LD) with SNPs associated with breast cancer (those near ESR1 and PTHLH), and a third (ZNF365) is near, but not in LD with, a breast cancer SNP. 22747683

2012

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker CTD_human Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth. 22267197

2012

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Here, we demonstrate in mice pleiotropic involvement of PTHrP in key steps of breast cancer - it influences the initiation and progression of primary tumors and metastases. 22056386

2011

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Methylation of the PTHrP P2 is a potential marker of breast cancer progression and might be used to evaluate the metastatic potential of breast tumors. 21775817

2011

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast cancer cells. 20401668

2011

Entrez Id: 5744
Gene Symbol: PTHLH
PTHLH
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Here, we demonstrate that PTHrP is also closely involved in breast cancer initiation, growth and metastasis through mechanisms separate from its bone turnover action, and we suggest that PTHrP as a facilitator of oncogenes would be a novel target for therapeutic purposes. 21901625

2011