Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE The expression of β-catenin and STT3A/B in colon cancer tissues was initially detected by immunohistochemistry, followed by correlation analyses of the survival rate with the expression of β-catenin and STT3A/B as well as identification of the interaction between β-catenin and STT3A/B. 31812723

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Mechanically, TIPE1 directly targets β-catenin and promotes β-catenin degradation in a protease-dependent manner, and Wnt/β-catenin signaling plays a crucial role during TIPE1-mediated stemness inhibition in colon cancer. 31111874

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Opposing Regulation of Cancer Properties via KRT19-Mediated Differential Modulation of Wnt/β-Catenin/Notch Signaling in Breast and Colon Cancers. 30650643

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In conclusion, targeting CBP/β-catenin, combined with PD-1/PD-L1 immune checkpoint blockade, shows potential as a new therapeutic strategy for treating liver metastasis during colon cancer. 31105882

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Importantly, we identified that ER-NLR regulate Wnt/β-catenin pathway in colon cancer. 31121307

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Selective Wnt/β-catenin Small-molecule Inhibitor CWP232228 Impairs Tumor Growth of Colon Cancer. 31262892

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE PRRX2 and β-catenin in patients with the liver metastases of colon cancer was detected by immunochemistry. 31471104

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In this study, we synthesized Dicer-substrate siRNA conjugated with palmitic acid at the 5'-end of the sense strand (C16-DsiRNA), and examined its RNAi effect on β-catenin as a target gene in a colon cancer cell line, HT29Luc, both in vitro and in vivo. 30560565

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Colon cancers with nuclear β-catenin accumulation demonstrated greater radio-resistance with a higher number of CSCs. 31810923

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE In addition, PIK3CD expression in colon cancer tissues positively correlated with β-catenin abnormal expression, which was an independent predictor for OS of colon cancer patients. 30618098

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE By an in silico study, we present here a possible mechanism of interaction between the sesame lignans and β-catenin leading to inhibition of formation of the said complex, thereby elevating some of these ligands as potential lead molecules in the development of drugs for treatment of colon cancer. 29455637

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer. 31351496

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE We analyzed the correlation between ACLY and CTNNB1 protein in 78 colon cancer patients by Pearson correlation. 31511060

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE We propose that inhibition of the WNT pathway, particularly β-catenin, may bypass resistance to MEK inhibition in human PIK3CA mt colon cancer. 30944457

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE <i>Conclusion</i>: ZEB2-AS1 could promote colon cancer cell proliferation and inhibit apoptosis to promote the progression of colon cancer by upregulating the expression of β-catenin protein. 31698657

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Overall, the current study has identified activation of the Wnt/β-catenin pathway as a novel fundamental cause of colon cancer resistance to BRAF inhibition. 29167314

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Immunohistochemical staining and western blotting experiments revealed that in colon cancer cells with SNHG1 knockdown, β-catenin, c-Myc and cyclin D1 protein levels were decreased, while E-cadherin was increased, which suggested that SNHG1 promoted colon cancer cell proliferation, migration and invasion through the Wnt/β-catenin signaling pathway. 29749530

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Colon cancer cells secrete and express high levels of β-catenin, which may stimulate autocrine signaling and further enhance activities of the canonical Wnt signaling pathway. 29808797

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Our results indicate the utility of CDK8 inhibitors for the treatment of colon cancer metastases in the liver and suggest that CDK8 inhibitors may be considered in other therapeutic settings involving TGFβ/SMAD or Wnt/β-catenin pathway activation. 30185549

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Results demonstrate that milimolar concentrations of butyrate has an anti-proliferative effect in all three colon cancer cell lines under study, leading to a decrease on cell viability, expression of P21, P53 and β-catenin, being able to modulate P-glycoprotein activity and to induce apoptosis by modulation of BAX/BCL-2 ratio. 29587241

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE AFAP1-AS1 knockdown also increased the expression of E-cadherin and ZO-1 while inhibited the expression of Vimentin, MMP9, ZEB1 and β-catenin, suggesting that AFAP1-AS1 is involved in the epithelial-mesenchymal transition (EMT) process of CC. 30588252

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE A Positive Feed-Forward Loop between LncRNA-CYTOR and Wnt/β-Catenin Signaling Promotes Metastasis of Colon Cancer. 29606502

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Our retrospective tumor-specimen analysis elucidated alteration in the expression of bone morphogenetic protein 2 (BMP-2) and β-catenin during the colon cancer progression, indicating that their possible intervention through "forced differentiation" in colon cancer remission. 29457276

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts. 29044515

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE MiR-155 directly regulates β-catenin at the transcriptional level, and promotes the invasion potential of colon cancer cell, at least partly through the upregulation of β-catenin. 29364476

2018