Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such as colon cancer. 25589625

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because of feedback activation of EGFR. 26365186

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Following exposure of gastric and colon cancer cell lines to LPS- and IL-10-stimulated human macrophages, either by indirect contact or conditioned media, we analyzed the effect of the different macrophage populations on cancer cell invasion, migration, motility and phosphorylation status of EGFR and several interacting partners. 26043921

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Further, active targeting against CD44 and EGFR receptors was validated in breast and colon cancer cell lines. 26238079

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE These results indicate that ERBB3 is a potential target for EGFR- and ERBB2-resistant colon cancer therapy. 24970817

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. 25200834

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE Through biochemical and cellular pharmacologic studies, we have determined that cells harboring the colon cancer-derived G719S and G724S mutants are responsive to cetuximab therapy in vitro and found that the requirement for asymmetric dimerization of these mutant EGFR to promote cellular transformation may explain their greater inhibition by cetuximab than small-molecule kinase inhibitors. 24894453

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. 25535899

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling. 25301722

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Here we show a clear correlation between the efficacy of anti-EGFR inhibitors with their ability to inhibit STAT3 activity in A431 epidermoid carcinoma cells and in a series of wt K-RAS expressing human colon cancer cell lines. 24556630

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In contrast, forced expression of MITF in melanoma and colon cancer cells inhibited EGFR and conferred sensitivity to BRAF/MEK inhibitors. 25789707

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 PosttranslationalModification BEFREE In the present study, effects of concomitant inhibition of the epidermal growth factor receptor (EGFR) and DNA methyltransferase were examined in human colon cancer cells. 24874286

2015

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE ADCC was measured by chromium-51 release on a epidermal growth factor receptor (EGFR)-positive human colon cancer cell line. 23296156

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Cetuximab is a monoclonal epidermal growth factor receptor (EGFR)-targeting antibody, used in the treatment of colon cancer. 24595598

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE When bound with biotinylated cetuximab these spores could specifically target to the epidermal growth factor receptor on HT 29 colon cancer cells, thereby delivered paclitaxel to the cells with 4-fold higher efficiency, as indicated by fluorescent intensity of paclitaxel Oregon Green 488 bound to HT29 cells. 23480726

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE The use of epidermal growth factor receptor-targeted therapy in advanced colon cancer patients requires knowledge of the mutation status for KRAS and BRAF genes, and knowing the mutational status of PIK3CA may predict how patients respond to aspirin to prevent colon cancer recurrence. 24355100

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE EGFR inhibition has proven beneficial across a number of gastrointestinal malignancies; and has shown specific advantages among KRAS wild-type genetic subtypes of colon cancer. 24960403

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Differential regulation of EGFR-MAPK signaling by deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) in colon cancer. 25027205

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules. 24792576

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE Mostly, we verified a higher frequency rate of the KRAS(G13) and EGFR A13_del oncogene mutations in right colon cancer; whereas KRAS(G12) codon mutation occurs more frequently in left colon cancers. 23572025

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 PosttranslationalModification BEFREE In that respect, pmAb impedes the signaling cascade mediated by EGFR intracellular phosphorylation and activity of focal adhesion kinase (FAK) as well as the EGF-induced invasive and migratory potential of colon cancer cells. 22956286

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE The results of these studies suggest that combined treatment of BRAF(V600E)-driven colon cancers with both vemurafenib and EGFR inhibitors is worth clinical evaluation. 23074264

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Negative experience of dual EGFR and VEGF targeting in colon cancer cannot be overlooked. 23518595

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE The impact of KRAS mutations on the efficacy of therapies that target the epidermal growth factor receptor (EGFR) is a major, ongoing area of oncology research, aimed at identifying the best possible treatments for individual colon cancer patients. 23636143

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Preclinical studies demonstrated synergistic activity of cetuximab and erlotinib cotreatment on growth inhibition of colon cancer cell lines both as a result of enhanced inhibition of the epidermal growth factor receptor pathway and differential effects on STAT3. 22412142

2012