Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE To determine the role of CD133 in colon cancer, we silenced CD133 in human colon cancer cells. 31736063

2020

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Using three independent primary spheroidal colon cancer cultures that expressed a Wnt reporter construct we observed high Wnt activity was associated with the cell surface markers CD133, CD166, and CD29, but not CD24 and CD44, while the original study found all five markers were correlated with high Wnt activity (Figure 2F; Vermeulen et al., 2010). 31215867

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE CD133+ colon cancer cells (LoVo) were infected with the lentiviral vector carrying CD133 gRNA and purified cell by culturing single cell colonies. 31393941

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE CD133 expression was evaluated by flow cytometry in three colon cancer cell lines (HCT116, Lovo and DLD1). 27387378

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Together, our present observations strongly suggest that the CD133-PTPRK axis plays a pivotal role in the regulation of colon cancer progression as well as drug resistance. 30947381

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE CD133 was considered colon cancer stem cell marker and used to sort CD133+ and CD133- cells by magnetic cell sorting. 31390540

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE CD133-containing MVs induced the development of chemoresistance by abolishing the inhibitory effects of anti-epidermal growth factor receptor (EGFR) drugs on cell proliferation and motility in colon cancer. 30521383

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE The colon cancer stem cells were successfully sorted, and the content of CD133+ in colon cancer stem cells reached 80.3%. 30941956

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE On the whole, our data indicated that patients with colon cancer with CD133-negative expression had a reduced disease-free survival. 29328371

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE We found that RAC3 overexpression was mainly associated to CD133+ side-population of colon cancer cells and also to early and advanced stages of colon cancer, involving increased expression of mesenchymal and stem markers. 29464039

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE In conclusion, p-STAT3 may participate in the progression of the early stage of colon cancer through the up-regulation of CD133, which in turn induces survivin expression. 29432737

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Although the <i>TP53</i> gene is frequently mutated in colon cancer, it remains not fully understood whether and how tumor protein p53 (p53) is associated with CD133 expression in colon cancer cells. 29928431

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Assessment of neutralizing interleukin-4 effect on CD133 gene expression in colon cancer cell line. 28578295

2017

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE CD133 and CD44 were regarded as markers of CCSCs and they were found to be co-expressed in the HCT116 colon cancer cell line. 27600678

2016

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In summary, CD44(high)/CD133(high) cells isolated from HCT-116 cells harbor CSC properties that may be related to the tumor growth of colon cancer. 26840024

2016

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE However, sorted CD133+ colon cancer cells exhibit no increased resistance to 5-FU, and CD133 levels exhibit no correlation with colon cancer patient survival or cancer recurrence. 27659530

2016

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE To elucidate the role of CD133 expression in chemoresistance, we silenced the CD133 expression in a colon cancer cell line and determined its effect on the biological characteristics downstream. 26002465

2015

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases. 25625240

2015

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Together, our findings indicate that FOXM1, PRDX3, and CD133 are potential therapeutic targets for the elimination of CSCs in colon cancer. 26350748

2015

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE In this study, we evaluate and comparing nucleostemin expression in CD133+ and CD133- colon cancer cell line HT29. 24762489

2014

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE CD133-positive cancer stem cells in colon cancer are resistant to conventional chemotherapy. 23245395

2013

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE CD66c was absent in CD133-positive cells that were isolated from normal colon, whereas its expression was brightest (CD66c(bright) ) in CD133-positive cells from colon cancer samples. 23027178

2013

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence. 22231565

2013

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE According to the cancer stem cell (CSC) model, higher CD133 expression in tumor tissue is associated with metastasis and poor prognosis in colon cancer. 23577199

2013

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Studies have shown that the expression of CD133, leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5), and ATP binding cassette (ABC)G2 proteins is associated with malignancy and poor prognosis in colon cancer. 23619912

2013