Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE The low frequency of the APOE ∊4 allele may suggest a low genetic risk of Hakka population for cardiovascular disease, Alzheimer's disease, and other diseases. 30508003

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Inherited abnormalities in apolipoprotein E (ApoE) or low-density lipoprotein receptor (LDLR) function result in early onset cardiovascular disease and death. 30654068

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease. 30598326

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear. 30232753

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE The apolipoprotein E (APOE) gene ɛ4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. 31381519

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE We found in separate models that women were significantly more likely to have AD and CVD pathology than men, and men were more likely to have "pure" Lewy Body disease, in models adjusted for age at death, education, race, and the APOE-e4 allele. 31128096

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes. 31521122

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Low levels of HDL cholesterol, adjusted for ApoE and the above mentioned variables, associated with higher prevalence of CVD (aOR=1.35, 95%CI 1.00, 1.83) and all-cause mortality (aHR=1.42, 95%CI 1.14, 1.78). 31585002

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE APOE genotype was associated with baseline lipid fractions (e.g. mean difference(95%CI) in LDL(mg/dL) for ε2 versus ε33: -17.1(-18.1-16.0), and ε4 versus ε33: +5.7(4.8;6.5)), but the association between APOE and mortality was unaltered after adjustment for baseline LDL or cardiovascular disease. 31356640

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Genome-wide association (GWAS) and whole-genome sequencing (WGS) studies on centenarians pointed toward the inclusion of the apolipoprotein E (<i>APOE</i>) polymorphisms ε2 and ε4, as implicated in the attainment of extreme longevity, which refers to their effect in age-related Alzheimer's disease (AD) and cardiovascular disease (CVD). 30884759

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Although apolipoprotein E4 (ApoE4), one of the isoforms coded by a polymorphic APOE gene, has been widely recognized as a risk factor for cardiovascular diseases and as an immunoinflammatory factor, less is known regarding how ApoE4 affects atherosclerosis in periodontitis patients. 30503976

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Apolipoprotein E (APOE) gene polymorphism is associated with neurodegenerative and cardiovascular diseases. 31625294

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Therefore, in this narrative review, we discuss how omega-3 fatty acid intake and physical activity may modify the impact of ApoE ɛ4 on AD and CVD risk. 30321297

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 AlteredExpression BEFREE These findings suggest that epigenetic modification of ABCG1 and APOE may play a role in the pathway from disturbed blood lipid levels to the development of cardiovascular diseases. 31823830

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE We estimated the risk of dementia in relation to SBP variation measured at different time windows (i.e., at least 0, 5, 10, and 15 years) prior to dementia diagnosis, with adjustments for age, sex, education, apolipoprotein E (APOE) genotype, vascular risk factors, and history of cardiovascular disease. 31714941

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE The future of apolipoprotein E mimetic peptides in the prevention of cardiovascular disease. 31157629

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE The APOE4 allele is not only the strongest genetic risk factor for AD, it also affects risk for cardiovascular disease, stroke, and other neurodegenerative disorders. 30844401

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE APOE differentially affects type and timing of CVD-related neuropathology. 30321502

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Due to the presence of different APOE isoforms in human population, understanding APOE's role in pathological processes represents not only a challenge, but a demand for further development of therapeutic strategies for cardiovascular diseases. 30213474

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE The apolipoprotein E-deficient (apoE-/-) mouse model has advanced our understanding of cardiovascular disease mechanisms and experimental therapeutics. 29166645

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE LSR gene is located upstream of APOE, an important risk factor for cardiovascular disease (CVD). 29178324

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE We found that higher DNA methylation levels in the promoter region of APOE increase the odds of dementia and AD, but not CVD. 29509901

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Abbreviations: PVAT: perivascular adipose tissue; ApoE: apolipoprotein E deficient mouse strain; Control: C57Bl/6J mouse strain; PTA: 0.3% phosphotungstic acid; microCT: micro-computed tomography; CV: cardiovascular; CVD: cardiovascular disease; IQR: interquartile range; PPARγ: peroxisome proliferator activated receptor - gamma; VV: vasa vasorum; 3D: three dimensional. 29956579

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Different isoforms of ApoE have been associated with susceptibility to various diseases including Alzheimer's and cardiovascular diseases. 30496280

2018