Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Additionally, miR-103a-3p, miR-127-3p, miR-17-5p and miR-18a-5p were discovered significantly up-regulated in CRC tissues; while miR-17-5p, miR-181a-5p, miR-18a-5p and miR-18b-5p were significantly elevated in CRC plasma exosomes. 30458288

2019

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE A statistically significant inverse correlation between KCNMA1 expression and mir-17-5p levels was observed in patients with CRC. 30791468

2019

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE <b>Conclusions:</b> Our study indicated that upregulated miR-17 may promote the progression of CRC and may exert its function as a tumor suppressor miRNA by targeting <i>SIK1</i>. 31118777

2019

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Among the eight tested miRNAs, the mean stool levels of miR-21, miR-92a, miR-144*, and miR-17-3p differed significantly between the CRC group and the control group (p =0.014, 0.001, <0.001, and 0.008, respectively). 31216561

2019

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE HAPS and HAMSB showed CRC preventive effects, based on the reduced colonic oncogenic miR17-92 cluster miRNA expression, but there was no significant diet-induced differences in the colonic O<sup>6</sup>MeG adduct levels. 31052187

2019

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Firstly, miR‑17‑3P expression was aberrantly upregulated in human CRC tumor tissues compared with controls. 29115593

2018

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE We provide evidence for associations between early regional LNM and high expression levels of the miR-17/92 cluster members: miR-17-3p and miR-92a, in the invasive front of CRC. 29902577

2018

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The current evidence suggests that circulating miR-17 has the potential diagnostic value for CRC. 29808806

2018

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE MiR-192, miR-200c and miR-17 are fibroblast-mediated inhibitors of colorectal cancer invasion. 30473751

2018

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer. 29367070

2018

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer. 26804172

2016

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE In conclusion, miR-106a/b, miR-20a/b, and miR-17 contribute to the proliferation and invasion of colorectal cancer by targeting their common target gene, GABBR1, and played a critical role in the proliferation and invasion of colorectal cancer. 27230463

2016

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Furthermore, miR-17-5p (p = 0.011) and miR-20a-5p (p = 0.003) were up-regulated expression in the III/IV tumor stage, miR-145-5p (p = 0.028) and miR-195-5p (p = 0.001) were significantly increased expression with microscopic vascular invasion in CRC tissues, miR-17-5p (p = 0.037) and miR-145-5p (p = 0.023) were significantly increased expression with lymphovascular invasion. 26462034

2015

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Exosomal miR-17-92a cluster expression level in serum was correlated with the recurrence of CRC. 26057451

2015

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Then, we applied it on a gene expression dataset of colorectal cancer clinical patient samples and inferred the perturbed miRNA regulatory networks of colorectal cancer, including several known oncogenic or tumor-suppressive miRNAs, such as miR-17, miR-26 and miR-145. 25069957

2014

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Significantly higher expression levels of miR-17-5p were found in CRC patients with distant metastases and higher clinical stages. 24912422

2014

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Up-regulated miR-17 promotes cell proliferation, tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma. 22132820

2012

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The current findings suggest that miR-17-5p is a crucial determinant of colorectal cancer progression. 23250421

2012

Entrez Id: 406952
Gene Symbol: MIR17
MIR17
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Both miR-17-3p and miR-92 were significantly elevated in the patients with CRC (p<0.0005). 19201770

2009