Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE These findings indicate that LncRNA NEAT1 could target miR-34a and promote autophagy to facilitate 5-FU chemoresistance in CRC. 31802650

2020

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE In this study, we mainly focused on the potential roles of lncRNA- ZDHHC8P1 in the development process of colorectal cancer (CRC) via miR-34a. 30840269

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE It has been shown that downregulation of miR-34a occurs in varieties of cancers including colorectal cancer (CRC). 30880751

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE In conclusion, it was determined that miR-34 promoter methylation and TP53 polymorphisms may be associated with CRC pathogenesis. 30944658

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide. miR-34 induces changes of its downstream genes and plays a key role in altering the apoptotic cycle and pathways of downstream cells and therefore influences carcinogenesis. 31349954

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression. 31658284

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE In the present study, the levels of miR-34a expression were measured in various CRC cell lines. 31555358

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE COUP‑TFII promotes epithelial‑mesenchymal transition by inhibiting miR‑34a expression in colorectal cancer. 30968145

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Furthermore, we found that GAPLINC positively regulated the miR-34a target gene c-MET in CRC tissues. 29427222

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE We observed significantly greater expression of <i>TLR4</i>, <i>IL1B</i>, <i>IL8</i>, and miR-135b in CRA lesions and <i>TLR2</i>, <i>IL1B</i>, <i>IL6</i>, <i>IL8</i>, miR-34a and miR-135b in CRC tumours compared to their respective normal tissues. 30598580

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE miR-34a might function as a predictor of fluorouracil chemosensitivity in CRC, and a combination strategy of miR-34a with fluorouracil was expected to be more beneficial for CRC patients. 29511598

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The CRC-related SNHG7 and miR-34a might be implicated in CRC progression via GALNT7, suggesting the potential usage of SNHG7/miR-34a/GALNT7 axis in CRC treatment. 29970122

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE The results showed that the expression of miR-34a was downregulated whereas TGF-β1 and VEGF were upregulated in CRC tumor tissues and peripheral blood macrophages. 30523755

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE C/A SNP of miR-34a could promote CRC cell proliferation by up-regulation of E2F1. 28293146

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE We found SAMe and MTA raised miR-34a/b expression in CRC cell lines, inhibited migration and invasion <i>in vitro</i> and liver metastasis <i>in vivo</i>. 29108270

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Expression levels of Smad4 and miR-34a in CRC patients had a significant inverse correlation and overexpressing miR-34a inhibited macroautophagy activation by directly targeting Smad4 through the TGF-β/Smad4 pathway. 28348487

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE We analyzed data on human colorectal carcinomas from the Cancer Genome Atlas collection to determine whether expression of PPP1R11 was affected by altered level or activity of p53, markers of epithelial-to-mesenchymal transition (EMT), or MIR34A or was associated with metastasis. 28435028

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE At the same time, 332 DEGs (188 upregulated and 144 downregulated) were screened out between miR-34a transformed CRC and miR-34a non-transfected CRC samples and they were enriched in 20 GO terms and eight KEGG pathways. 29197895

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE In addition, genes encoding miRNA important for epithelial mesenchymal transition and other metastasis-related effects, such as mir-9, miR-34 and miR-210 can be good candidates for associating their DNA methylation profiles with CRC metastasis. 28364795

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling. 28781671

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE We previously reported that IL-6R, STAT3 and miR-34a form a positive feedback-loop, which promotes epithelial to mesenchymal transition (EMT), invasion, and metastasis of colorectal cancer (CRC) [1]. 26091352

2015

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5, thus providing new insight into the molecular mechanisms underlying CRC progression and establishing a strong potential for the application of miR-34a as a novel therapeutic marker against CRC. 26103003

2015

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Moreover, the expression of miR-34a-5p was an independent prognostic factor for CRC recurrence by multivariate analysis (P<0.001 for cohort I, P=0.007 for cohort II). 25362853

2015

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. 25712055

2015

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE MiR-34a was significantly downregulated and pY397FAK was upregulated in CRC cancer tissues. 24370784

2014