Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE The combination of resveratrol with a PPARγ agonist could be a promising pharmacological approach for treatment of colorectal cancer. 24975132

2015

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Our results provide new evidence of association between PPARG variants and colorectal cancer risk. 24045924

2014

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARγ and TNFα signaling. 24133572

2014

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer. 24631504

2014

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Thus, codeficiency of Cav1 and adenomatous polyposis coli facilitated formation of CRC, and activation of PPARg may offer novel strategies for treatment of CRC. 23640045

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer. 23583560

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 PosttranslationalModification BEFREE UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression. 22286757

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells. 21765467

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Epigenetic silencing of peroxisome proliferator-activated receptor γ is a biomarker for colorectal cancer progression and adverse patients' outcome. 21151932

2011

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Peroxisome proliferator-activated receptor-gamma 34C>G polymorphism and colorectal cancer risk: a meta-analysis. 20440859

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE We have investigated the therapeutic properties of 5-[[6-[(2-fluorophenyl)-methoxy]-2-napthalenyl]-methyl]-2,4-thiazolidinedione (MCC-555) a PPARgamma agonist in human colorectal cancer cells. 20385121

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE We report a novel PPARG germline mutation in a patient affected by colorectal cancer that replaces serine 289 with cysteine in the mature protein (S289C). 20123124

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE The aim of our study was to investigate the involvement of peroxisome proliferator-activated receptor gamma (PPARgamma) in mesalazine's anticarcinogenic actions in colorectal cancer cells. 18544567

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells. 18360708

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Although PPARgamma agonists may not by themselves be capable to induce clinical tumor regression, their combination with chemotherapy drugs or other targeted therapies is worth pursuing in the treatment of colorectal carcinoma. 17659359

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE PPARgamma agonists have been shown to reduce the growth of colorectal carcinoma cells in culture and in xenograft models. 17390024

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality. 17290397

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells. 17565986

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE These results suggest that PPARgamma inhibitors are a novel potential antimicrotubule therapy for CRC that acts by directly reducing microtubule precursors. 17096328

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E), and PPARgamma (Pro12Ala) genes and the risk of CRC. 16937502

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE These data suggest that PPARgamma may be associated with many aspects of colorectal cancer including insulin- and inflammation-related mechanisms. 16489531

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. 16965392

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker CTD_human We hypothesize that the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with colorectal cancer given its association with insulin, diabetes, obesity, and inflammation. 16489531

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells. 16520894

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker CTD_human These data suggest that PPARgamma may be associated with many aspects of colorectal cancer including insulin- and inflammation-related mechanisms. 16489531

2006