Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 Biomarker BEFREE It remains unresolved how AIM2 acts on CRC metastasis. 31210372

2019

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 Biomarker BEFREE Yet, the roles of the AIM2 inflammasome in IBD and the early phases of colorectal cancer remain ill-defined. 27524110

2017

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 AlteredExpression BEFREE Chemotherapy is a predominant strategy to treat cancer and is often associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies.Lian et al. recently explored the immune-mediated mechanisms of Irinotecan-induced diarrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2. 28524163

2017

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 Biomarker BEFREE Our data suggest that AIM2 plays a critical role as a tumor suppressor and might serve as a potential therapeutic target in CRC. 28243117

2017

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 AlteredExpression BEFREE Spearman analysis indicated that there was a negative correlation between AIM2 expression and preoperative serum carcino-embryonic antigen (CEA) levels in CRC patients (r=-0.217, P=0.009). 28802238

2017

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 AlteredExpression BEFREE The expression of NLRC3, a checkpoint of inflammation, and the inflammasome components NLRP1, NLRP3, NLRC4 and AIM2 were reduced in CRC. 26378020

2015

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 AlteredExpression BEFREE Expression of ISGs correlated with expression of AIM2 in 10 different IFN-γ treated colorectal cancer cell lines. 21804607

2012

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 Biomarker BEFREE Moreover, AIM2 reduces breast cancer cell proliferation and mammary tumor growth in a mouse model and shows a high frequency of frameshift mutations in microsatellite unstable (MSI-H) gastric, endometrial and colorectal cancers. 19795419

2010

Entrez Id: 9447
Gene Symbol: AIM2
AIM2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.090 PosttranslationalModification BEFREE These results demonstrate that inactivation of AIM2 by genetic and epigenetic mechanisms is frequent in MMR-deficient colorectal cancers, thus suggesting that AIM2 is a mutational target relevant for the progression of MSI-H colorectal cancers. 17726700

2007