Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Long-term follow-up and safety assessment of angiogenic gene therapy trial VIF-CAD: Transcatheter intramyocardial administration of a bicistronic plasmid expressing VEGF-A165/bFGF cDNA for the treatment of refractory coronary artery disease. 31288177

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE For that, mouse BM cells were transduced with lentiviral vectors coding for <i>VEGFA</i> or sphingosine kinase (<i>SPHK1)</i>, which catalyzes S1P production, and injected them intravenously 4 and 7 days after cardiac ischemia-reperfusion in mice. 30786776

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta-analysis. 30035366

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association of genetic polymorphisms in vascular endothelial growth factor with susceptibility to coronary artery disease: a meta-analysis. 29973139

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Moreover, VEGF rs699947 and rs2010963 polymorphisms may serve as genetic biomarkers of poor collateral circulation after myocardial ischemia. 30317903

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE We conclude that controlled homogeneous VEGF delivery by FACS-purified transduced ASC is a promising strategy to achieve safe and functional angiogenesis in myocardial ischaemia. 29478261

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE In univariate analysis, all three VEGF polymorphisms (460C, 1154A, and 2578A) were significantly associated with a higher prevalence of coronary artery disease (P < .01) and greater frequencies of hypertension were found in carriers of the 1154A allele and the 2578A allele (P = .01). 28364978

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Vascular endothelial growth factor A polymorphisms are associated with increased risk of coronary heart disease: a meta-analysis. 28430629

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Genotyping of VEGF rs2010963 polymorphism was performed on 520 individuals, comprising 347 patients with documented coronary artery disease based on angiography report and 173 individuals with normal coronary arteries, using the TaqMan real-time PCR method. 27704620

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association of Genetic Polymorphisms on Vascular Endothelial Growth Factor and its Receptor Genes with Susceptibility to Coronary Heart Disease. 26726843

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE The aim of the present study is to analyze the relationships between functional polymorphisms in genes encoding basic fibroblast growth factor (bFGF, FGF2), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), platelet derived growth factor-B (PDGFB), transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor A (VEGF-A) and the severity of coronary atherosclerosis in patients with stable CAD undergoing their first coronary angiography. 27835972

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 AlteredExpression BEFREE We aimed to investigate the correlation between the levels of circulating miR-214 and the expression of vascular endothelial growth factor (VEGF) in the pathogenesis of coronary heart disease patients to further explore the mechanism involved in the vasculogenesis. 25575606

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Association between VEGF polymorphisms (936c/t, -460t/c and -634g/c) with haplotypes and coronary heart disease susceptibility. 25755796

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Dysregulated miR-361-5p/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease. 24865854

2014

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE In conclusion, VEGF microparticles and CoQ10 nanoparticles can be considered as promising strategies for managing MI. 23639291

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE We conclude that adenovirus-mediated VEGF direct myocardial administration to patients with severe coronary artery disease is safe, and future larger trials are warranted to assess efficacy. 23137122

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE However, clinical trials of VEGF gene therapy in patients with coronary artery disease or peripheral artery disease have not, to date, demonstrated clinical benefit. 23856679

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility. 23545315

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Vascular endothelial growth factor and its receptor the kinase domain receptor play critical roles in the pathogenesis of coronary artery disease. 21573804

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 AlteredExpression BEFREE VEGF gene mRNA expression in patients with coronary artery disease. 22711306

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Thymosin beta-4 (TB4) and vascular endothelial growth factor (VEGF) are linked to adult epicardial progenitor cell mobilization and neovascularization and is cardioprotective after myocardial ischemia. 21332365

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE We examined two VEGF polymorphisms, including +405 C/G (rs2010963) and -2578C/A (rs699947), to assess their relation to the extent of coronary atherosclerosis. 20489684

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 Biomarker BEFREE Epicardial fat was clearly different from substernal fat because there was a far higher expression of haptoglobin, prostaglandin D(2) synthase, nerve growth factor beta, the soluble vascular endothelial growth factor receptor (FLT1), and alpha1 glycoprotein but not of inflammatory adipokines such as monocyte chemoattractant protein-1, interleukin (IL)-8, IL-1beta, tumor necrosis factor alpha, serum amyloid A, plasminogen activator inhibitor-1, or adiponectin despite underlying coronary atherosclerosis. 20116810

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease. 20621071

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.400 GeneticVariation BEFREE In this study, we have analyzed the effect of 1154 A/G polymorphism of VEGF and 70 bp VNTR polymorphism of intron 3 in IL-4 genes in coronary heart disease (CHD) patients (n = 300) and their age matched controls (n = 300). 20364398

2010