Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Besides gene-level CD association P-values, association with AI diseases was the strongest predictor, highlighting generalized mechanisms of inflammation, and the interferon-γ pathway particularly. 25935003

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation BEFREE Previous studies have shown that polymorphisms in the Toll-like receptor (TLR), the apoptosis, the IL-23/IL-17 and the interferon gamma (IFNG) pathways are associated with risk of both CD and UC. 26698117

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Here, we demonstrate no quantitative difference in phenotype, in vitro growth kinetics and molecular signatures to IFNγ between MSCs derived from CD and healthy individuals. 25899824

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE These data are in concordance with the fact that CD has been shown to be associated with a Th1 T-cell-mediated inflammation model and high IL12/IFNγ production at histological affected sites. 25359546

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects. 26072972

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation BEFREE Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation. 25171510

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE The percentages of circulating Th1 (CD3+CD8-IFN-γ+) and Tc1 (CD3+CD8+IFN-γ+) cells were also higher in patients with active UC when compared with the percentages in patients with inactive UC and normal controls, although levels were lower than that in CD. 23446770

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE Basal levels of P2X7-R mRNA were higher in CD inflamed mucosa compared with noninflamed CD and controls and were upregulated after interferon-γ in controls. 24412990

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Quantitative gene expression analysis, by real-time PCR, of IL-32, IL-1β, IL-10, TNF-α and IFN-γ was performed on ileal biopsies of 15 AS and 15 Crohn's disease (CD) patients and 10 healthy subjects (HSs). 22847681

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Utility of in vitro interferon-γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease. 23176201

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Elevated IL-17A levels were positively correlated with IFN-γ in both inflammatory CD and UC but IL-17A and IFN-γ were correlated with IL-23p19 in CD ileum only. 21994045

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE IFN-γ is known not only to play an important role in the pathogenesis of Crohn's disease (CD), but also to increase permeability of the intestinal epithelial barrier. 22671596

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE IFN-γ was associated with the disease activity in UC, but did not reach significant level in CD. 21945121

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation BEFREE The Crohn's disease (CD) susceptibility gene, protein tyrosine phosphatase N2 (PTPN2), regulates interferon γ (IFNγ)-induced signalling and epithelial barrier function in T₈₄ intestinal epithelial cells (IECs). 21115548

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE In this study, we investigated the circulating IFN-γ and IL-12 production in 2 groups of Algerian patients with IBD (Crohn's disease and ulcerative colitis). 20626296

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Elevated levels of the pro-inflammatory cytokine, interferon-gamma (IFNgamma), are believed to be prominently involved in the pathogenesis of Crohn disease. 19654324

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE The reason for the decreased frequency of an in vitro T(H)-cell IFNgamma response toward E. coli proteins in peripheral blood of CD and AS patients, e.g., increased suppression needs to be clarified. 19079222

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression LHGDN Th1 cytokine/IFN-gamma levels in blood are lower in early onset Crohn's disease patients than in healthy children and are directly associated with disease-related clinical parameters. 18287963

2008

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression LHGDN intestinal macrophages expressing CD14 contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis 18497880

2008

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE An increased expression of interleukin-18 (IL-18), a proinflammatory cytokine inducing interferon-gamma, has been found in Crohn's disease (CD). 16306764

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE IL-2 and IFN-gamma were downregulated in PBMNC from CD and UC. 15827446

2005

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE The stimulatory effects of these cytokines on naive T cells in addition to a strongly synergistic action with IL-12 to trigger interferon-gamma production may contribute to the perpetuation of the inflammatory process in patients with CD. 15674109

2005

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Through the study of patients and mouse models, it has emerged that Crohn's disease is driven by the production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma), whereas ulcerative colitis is probably driven by the production of IL-13. 12876555

2003

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE Granzyme B mRNA levels correlated with interferon gamma mRNA levels in Crohn's disease. 10657017

2000