Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE Two-thirds of 46 GWAS candidate genes examined were expressed in human islets, and 11 of these significantly changed expression levels following exposure to proinflammatory cytokines (IL-1β + IFNγ + TNFα) for 48 h. Using the GWAS single nucleotide polymorphisms (SNPs) from each locus, we constructed a genetic risk score based on the cumulative number of risk alleles carried in children with newly diagnosed T1D. 26904692

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE T cells secreting the cytokines IFN-γ and IL-10 in response to seven peptides known to elicit T cell responses in type 1 diabetes were quantified by cytokine ELISPOT in HLA-typed patients characterized for Abs to IA-2 epitopes. 25225671

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines such as IL-1β and IFN-γ contributes to β-cell apoptosis. 24462878

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE A high proportion of new-onset T1D subjects mounted an inflammatory IFN-γ response much more frequently to one of the mimotope peptides than to the natural peptide. 25831495

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE IGRP(265-273)-specific CD8 T-cells that were cloned from the peripheral blood of a recent onset T1D individual were shown to secrete IFNγ and Granzyme B after antigen-specific activation and lyse HLA-A2-expressing murine islets in-vitro. 23155466

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes. 22150609

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Proinflammatory cytokines (IL-1β and IFN-γ) that mediate β-cell dysfunction in T1D down-regulated HIP14 expression in insulin-secreting INS-1 cells and in isolated rat and human islets. 21705657

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE The frequency of Tregs in peripheral blood was comparable but the FOXP3(+)IFN-γ(+) fraction was significantly increased in patients with type 1 diabetes compared to healthy controls. 21368230

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE On the other hand, higher ketoacidosis at onset, younger age at onset, and higher levels of tumor necrosis factor-alpha and interferon-gamma were observed in T1D patients carriers of G allele in comparison with the carriers of AA genotype. 19136037

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE The increased IFN-gamma response and lower IL-4 response toward diabetes-related autoantigens shown in CTLA-4 +49 GG risk subjects show a possible mechanism for the association between CTLA-4 and T1D. 17659059

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Interleukin (IL)-18 is a potent pro-inflammatory cytokine capable of inducing interferon-gamma production that is associated with the development of T1DM. 17373930

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE Several polymorphisms in regions where Th1 cytokines (IL12B and IFNG genes) are located were analyzed in 303 Spanish subjects with type 1 diabetes and compared with a control cohort (n = 548). 16216674

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE In the present report, we have adopted a linkage disequilibrium (LD) mapping approach to test for an association between T1D and three regions encompassing 13 interferon alpha (IFNA) genes, interferon omega-1 (IFNW1), interferon beta-1 (IFNB1), interferon gamma (IFNG) and the interferon consensus-sequence binding protein 1 (ICSBP1). 16504056

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes. 16907917

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE The gene encoding interferon (IFN)-gamma, IFNG, is known as one of the candidate susceptibility genes for type 1 diabetes. 15241679

2004

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE Polymorphisms of interferon-gamma gene CA-repeat and interleukin-10 promoter region (-592A/C) in Japanese type I diabetes. 11821159

2002

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type I diabetes. 11317661

2001

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker MGD IFN-gamma affects homing of diabetogenic T cells. 11714835

2001

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Overwhelming production of IFN-gamma seen in peripheral blood mononuclear cells from high-risk first-degree relatives of children with Type I diabetes suggests a Th1-like immune deviation in the prediabetic phase. 10907120

2000

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes. 10714554

2000

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Further studies are needed to confirm whether increased IFN-gamma mRNA in Th1-like lymphocytes stimulated with this specific GAD-peptide play a role in the cell-mediated immune response seen in children early after the onset of IDDM. 9699087

1998

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation BEFREE Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood. 9058314

1997

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker RGD The role of endogenous interferon-gamma (IFN gamma) in the development of insulin-dependent diabetes mellitus (IDDM) in diabetes-prone BB rats was evaluated. 8977415

1997

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Dominant TCR alpha-chain clonotypes and interferon-gamma are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus. 8968689

1997