Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE AZD1775 also selectively inhibited the proliferation of patient-derived primary cell lines from gliomas with naturally occurring ATRX mutations, indicating that the synthetic lethal relationship between WEE1 and ATRX could be exploited in a broader spectrum of human tumors. 31551363

2020

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Our findings reveal novel pathogenic mechanisms driven by ATRX deficiency in glioma, while also pointing to tangible strategies for drug development. 30808951

2019

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE However, CDKN loss, ATRX mutation and coexisting gain of chromosome 7/loss of chromosome 10 showed no clinical significance in this glioma entity. 30298540

2019

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Mutations of telomerase reverse transcriptase (TERT) and the α thalassemia/mental retardation syndrome X-linked (ATRX) genes have been the subject of numerous studies on the classification and prognosis of glioma. 30655743

2019

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Translation of these findings to patients with IDH1<sup>132H</sup> glioma harboring TP53 and ATRX loss could improve the therapeutic efficacy of radiotherapy and, consequently, patient survival. 30760578

2019

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma. 29545335

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner. 30226859

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE ATRX in lower-grade gliomas could be predicted using radiomic analysis. 29404769

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE In the current study, we performed ATRX-IHC in 78 gliomas whose ATRX statuses were comprehensively determined by whole exome sequencing. 29550880

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE The presence of ATRX mutations in glioma serves as a marker of better prognosis with longer patient survival although the underlying mechanisms are poorly understood. 29378238

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE p-Hsp27 is a novel biomarker of glioma and might have important clinical value for further classification of patients with wild-type IDH1 and normal ATRX expression, for evaluating prognosis and for guidance for adjuvant therapy. 29550762

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE We anticipate new treatments and clinical approaches will emerge for glioma and other cancer types as mechanistic and molecular studies on ATRX are only just beginning to reveal the many critical functions of this protein in cancer. 29889582

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE The classification of gliomas has been restructured with the discovery of isocitrate dehydrogenase (IDH) 1/2 mutations in the vast majority of lower grade infiltrating gliomas and secondary glioblastomas (GBM), with IDH-mutant astrocytomas further characterized by TP53 and ATRX mutations. 29521646

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE To evaluate arterial spin labeling (ASL) perfusion and dynamic contrast-enhanced (DCE) perfusion in glioma grading according to the previous WHO classification of 2007, as well as concerning isocitrate dehydrogenase (IDH) mutation status and ATRX expression as required by the new WHO 2016 brain tumor classification. 28488024

2018

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE One hundred seventy six cases of glioma were assessed for ATRX immunohistochemistry and subdivided into positive, negative and mosaic/heterogeneous staining patterns. 26833422

2017

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE The Role of ATRX in Glioma Biology. 29034211

2017

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. 26936505

2016

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE The results indicate immunohistochemical analysis including IDH1/2, ATRX, p53, and Ki-67 index is valuable for the classification of diffuse gliomas, which is useful for the evaluation of prognosis, especially Grade III gliomas and lower-grade gliomas (i.e., Grade II and III). 26968173

2016

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Our results showed ATRX-related regulatory functions of the combined profiles from DNA methylation and mRNA expression in astrocytic tumors, and delineated that loss of ATRX impacted biological behaviors of astrocytic tumor cells, providing important resources for future dissection of ATRX role in glioma. 25971279

2015

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE Subsequent subgroup analysis largely confirms many of the currently used molecular classification schemes for diffuse gliomas (ATRX or TP53 mutations, 1p19q codeletion). 26699864

2015

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE Recently, mutations of the ATRX gene have been found in various subtypes and grades of gliomas and were shown to refine the prognosis of malignant gliomas in combination with IDH and 1p/19q status. 24559763

2014

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker CTD_human The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. 24705251

2014

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker CTD_human Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. 23583981

2013

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE In adults, ATRX aberrations were detected in 33 % of grade II and 46 % of grade III gliomas, as well as in 80 % of secondary and 7 % of primary GBMs. 22886134

2012

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma. 23104868

2012