Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE The ING4/PTEN double tumor suppressors mediated by adenovirus modified with RGD had a significantly synergistic antitumor effect on glioma. 28407709

2020

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE This symbiotic glioma-macrophage interplay provides therapeutic targets specifically for PTEN-deficient GBM. 31185211

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE miR-21 may regulate the proliferation and apoptosis of human glioma cells by downregulating the expression of the PTEN protein, and miR-21 may represent a potential therapeutic target for the treatment of glioma. 28534371

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Then, we also analyzed the impact of TERT promoter mutations, PTEN deletion, EGFR amplification and MGMT promoter methylation in diagnosis, prognosis and response to therapy in glioma molecular subgroup. 31623593

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE We modified an immune-competent, genetically-driven mouse glioma model (forced PDGF expression + PTEN loss) where a portion of the tumor burden is irradiated (PDGF) and another un-irradiated luciferase expressing tumor (PDGF+Luciferase) is used as a readout of the abscopal effect following systemic anti-PD-L1 immunotherapy. 31793634

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE The expression of miR-26a and PTEN in glioma was quantified and the interaction among miR-26a, PTEN and PI3K/Akt signaling pathway was examined. 31101062

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. 30827889

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE We did whole exome sequencing for 11 GBM-PN cases and found that the percentage of TP53, PIK3CA, PIK3R1, or PTEN mutation in our GBM-PN cases (72.7%, 27.3%, 27.3%, and 27.3% respectively) was much higher than that in cases in TCGA GBM 2008, TCGA GBM 2013, and TCGA lower-grade glioma databases. 30715630

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma. 31469661

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 PosttranslationalModification BEFREE FGFR2-mediated phosphorylation of PTEN at tyrosine 240 contributes to the radioresistance of glioma. 31025173

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic activating mutations in PIK3CA. 30542720

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE The promotion of PTEN promoted the function of anti‑miR‑494 on glioma cancer cell growth through Akt/mTOR pathway. 30365133

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE The U87 culture supernatant promoted the M2 phenotype of THP1 cells. miR-32 was upregulated and PTEN was downregulated in THP1 cells with the M2 phenotype in the glioma microenvironment. 31218569

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma. 28423515

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE PTEN loss and EGFR amplification were distributed in different glioma histological groups. 26957305

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE Through comparative analyses of 286 cases of IDH-wildtype and IDH-mutant lower-grade glioma from a TCGA data set, we report that IDH-mutant gliomas have increased expression of tumor-suppressor genes (NF1, PTEN, and PIK3R1) and decreased expression of oncogenes(AKT2, ARAF, ERBB2, FGFR3, and PDGFRB) and glioma progression genes (FOXM1, IGFBP2, and WWTR1) compared with IDH-wildtype gliomas. 27852048

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE As expected, luciferase results verified the putative target site and also revealed the complementary binding between miR-19a and MEG3. miR-19a represses the expression of PTEN and promotes glioma cell proliferation, migration, and invasion. 28276316

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE Meanwhile, genetic ablation of miR-92b could restore PTEN expression and inhibit glioma growth. 28337377

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma. 28259931

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE In the current study, we show that co-expression of PIKE-A and CDK4 in TP53/PTEN double knockout GBM mouse model additively shortens the latency of glioma onset and survival compared to overexpression of these genes alone. 28368413

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway. 28887597

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway. 28121023

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE In addition, miR‑216b regulated phosphatidylinositol 3,4,5‑trisphosphate 3‑phosphatase and dual‑specificity protein phosphatase PTEN/protein kinase B signaling pathways in glioma. 29152659

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells. 27261630

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE Abnormal TUG1 expression was conducted in two glioma cells to analyze its regulation on miR-26a and PTEN using real-time PCR, western blot, and luciferase reporter assay. 27363339

2016