Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation BEFREE In uremic subjects, polymorphisms within the IFN-λ chromosomal region associate with spontaneous HCV clearance, similarly like in the non-uremic population. 30027841

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE By demonstrating that IFN-λ variation leaves a large footprint on the viral proteome, we provide evidence of pervasive viral adaptation to innate immune pressure during chronic HCV infection. 31478832

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE The Brazilian Public Health Service provides freely αPEG-IFN to treat patients infected with HCV. 30243981

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE Treatment-emergent depression is a common complication in patients with chronic hepatitis C virus (HCV) infection undergoing antiviral combination therapy with IFN-α and ribavirin. 31332697

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 AlteredExpression BEFREE Sessions included: IFN-λ Biology, Therapy and Genetic Variation; IFN-λ and Hepatitis C Virus Infection; IFN-λ in Other Infections; and IFN-λ-Hepatic Fibrosis and Cancer. 30998425

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation BEFREE Genetic variants in the IFN-λ region have also been associated with hepatic inflammation and fibrosis from various etiologies, however, alleles that are linked with improved HCV clearance associates with worse inflammation and fibrosis. 31161939

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation BEFREE Variants of rs2111485 and rs1990760 at <i>IFIH1</i> may be associated with spontaneous HCV clearance in Chinese Han population, but have no effect on HCV clearance induced by IFN-<i>α</i>. 31539314

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE These observations present an apparent conundrum-when and how does a presumably good IFN, with anti-HCV activity, interfere with the ability to clear HCV? 31241411

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE Based on these findings, ribavirin-induced anti-RR autoantibody seems to be associated with a more frequent nonresponse to IFN-<i>α</i>/ribavirin therapy with a significant higher HCV viral load. 31081724

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE In conclusion, the Fib-4 score may predict early hematological adverse effects in HCV-infected patients on IFN-based triple therapy. 30657408

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation BEFREE An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α-dependent cure of hepatitis C virus infection. 30289470

2019

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation BEFREE We undertook a longitudinal prospective study of 33 individuals with chronic HCV treated with combination pegylated IFN-α, ribavirin, and telaprevir/boceprevir. 29263212

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE Our results suggest that HCV G3a along with immune responses such as cytokines in HCV patients should be taken into account when interpreting clinical data and IFN-based therapeutic response. 29147974

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE However, little information is available about the effect of alcohol on interferon-lambda (IFN-λ, type III IFN), a novel candidate for development of therapy for HCV infection. 29446489

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE After adjustment, HCV+ kidneys were 3.7 times more likely to be discarded than HCV- kidneys in the DAA era (adjusted relative rate, 3.363.674.02; P < 0.001); an increase from the IFN era (adjusted relative rate, 2.783.023.27; P < 0.001). 29912046

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE Ten patients with HCV (genotype 1) were vaccinated with monocyte-derived DCs, generated in the presence of IFN-α (IFN-DCs) and pulsed with recombinant HCV Core and NS3 proteins. 29164490

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE Peg-IFN/ribavirin was effective and tolerable for thalassemic HCV patients. 29097076

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE This study aimed to evaluate the real-world cost-effectiveness of IFN-based therapy according to the current strategies with PegIFN/RBV for "easy-to-treat" to provide a reference for application of future DAA development for IFN-eligible, treatment naïve HCV patients. 29861209

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation BEFREE Neutropenia is a haematologic disorder commonly reported in patients with chronic hepatitis C virus (HCV) infection treated with pegylated interferon alfa-2a (PEG-IFN α-2a). 29574886

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE Taken together, the results demonstrated that CA could modulate Keap1/Nrf2 interaction via increasing p62 expression, leading to stabilization of Nrf2 and HO-1 induction, and elicit IFNα antiviral response to suppress HCV replication. 29656059

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE We employed three virus derivatives-wild-type Jc1, interferon (IFN)-resistant virus IR, and high-replicative-fitness virus P100-in order to explore additional IFN-α-related virus inhibition mechanisms. pDCs inhibited HCV infectivity and replication and produced IFN-α. 30232187

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE IL28B genotyping may be use as predictors of response for IFN-based therapy and personalized treatment of hepatitis C patient. 29380700

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE Hepatitis C virus (HCV) clearance with IFN-based therapies reduces the incidence of hepatocellular carcinoma (HCC). 29205405

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation BEFREE This prospective, randomized, multicenter study indicated that FLV had no add-on effect when given with SMV/Peg-IFN/RBV combination therapy for genotype 1b HCV-infected patients. 28722780

2018

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker BEFREE We also plan to identify patient characteristics that contribute to the development of PEG-IFN α-2a-induced neutropenia in hepatitis C patients. 29872876

2018