Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.060 Biomarker BEFREE Native vs. PEG-ASP administered according to availability in each center were prospectively evaluated in adults with high-risk ALL. 29165013

2018
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.060 AlteredExpression BEFREE ASP and ATIII activity was measured in 76 children with ALL treated according to the ALL IC BFM 2002 protocol. 28060110

2017
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.060 Biomarker BEFREE Asparaginase (ASP) is a cornerstone in the treatment of acute lymphoblastic leukemia (ALL). 28440015

2017
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.060 Biomarker BEFREE The goals of this study were to assess the pharmacokinetics and pharmacodynamics of ASP and to mathematically model the dynamics between ASP and asparagine (ASN) in relapsed ALL. 19741605

2009
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.060 GeneticVariation BEFREE Thrombotic events (TEs) are serious secondary complications in children with acute lymphoblastic leukemia (ALL) who receive L-asparaginase (ASP) therapy; however, the prevalence of TEs has not been established. 12518376

2003
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.060 Biomarker BEFREE In conclusion, the presence of TEL/AML1 gene fusion in childhood precursor B-lineage ALL does not seem to be associated with a high in vitro drug sensitivity, except for ASP, indicating that these patients could benefit from treatment schedules with significant use of this drug. 10910927

2000