Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE This study was designed to evaluate the value of NLS-RARα in the early diagnosis of APL. 31654721

2020

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML-RARα fusion oncoprotein, leading to a block in cell differentiation. 31811682

2020

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE Further mechanistic studies show that CUDC-101 triggers caspase-dependent degradation of the promyelocytic leukemia-retinoic acid receptor alpha fusion protein. 31584454

2020

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE The literature review indicated that allogeneic hematopoietic stem cell transplantation might be a therapeutic method to treat APL with IRF2BP2-RARA fusion. 31447564

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE In this article we laid emphasis on the rearrangement of the RARα gene and its different fusion partners resulting in variant forms of APL, their implication in underlying molecular pathogenesis of APL and also the different diagnostic modalities that should be employed for their rapid and accurate diagnosis. 29700805

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE Genetic mutations on PML-RARα in acute promyelocytic leukemia (APL) are reported to associate with arsenic trioxide (ATO) or all-trans retinoic acid (ATRA) resistance. 30824184

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE While most cases of APL harboring the PML/RARA fusion respond to all-trans retinoic acid (ATRA), some variant RARA rearrangements are ATRA insensitive. 31447065

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE The survival of APL with RARA rearrangement is much better than without RARA rearrangement. 30575821

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE Overcoming this differentiation arrest has the potential to improve the long-term survival of patients, as is the case in acute promyelocytic leukemia (APL), which is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. 30940908

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE The outcome of acute promyelocytic leukemia (APL) has drastically improved following the identification of the PML-RARA oncogene as a key player in the pathogenesis of APL, and the subsequent introduction of all-trans retinoic acid (ATRA) as a therapeutic agent. 30572725

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE Promyelocytic leukemia-retinoic acid receptor α (PML-RARa) sets the cellular landscape of acute promyelocytic leukemia (APL) by repressing the transcription of RARa target genes and disrupting PML-NBs. 31635329

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE However, flourescence in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) studies were negative for transcripts promyelocytic leukemia (<i>PML</i>) gene and retinoic acid receptor alpha (<i>RARA</i>) or <i>PML-RARA</i> fusion. 31371984

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE Herein, we for the first time report that phenylarsine oxide (PAO) could effectively induce PLZF-RARα variant fusion protein degradation through ubiquitin proteasome degradation pathway by apoptosis, which indicates that PAO might be a potential candidate for the treatment of PLZF-RARα variant APL. 30869512

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE APL is a model for oncogene-targeted therapies: <i>all-trans</i> retinoic acid (ATRA) and arsenic both target and degrade its ProMyelocytic Leukemia/Retinoic Acid Receptor α (PML/RARA) driver. 30674471

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE This is the first report proving that expression of HSP90 isomers are directly and differentially repressed by PML/RARA, with critical results on cellular homeostasis of target proteins, such as AKT, in APL blasts. 30536958

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE Once the diagnostic suspicion of acute promyelocytic leukemia (APL) has been raised, international guidelines recommend prompt initiation of tailored therapy and supportive care, while awaiting for genetic confirmation of the diagnosis, and the identification of the specific PML/RARA isoform by reverse transcriptase polymerase chain reaction (RT-PCR). 30421475

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 AlteredExpression BEFREE Influence of bcr-3 PML-RARα transcript on outcome in Acute Promyelocytic Leukemia patients of Kashmir treated with all-trans retinoic acid and/or arsenic tri-oxide. 30803552

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE The promyelocytic leukemia (PML)-retinoic acid receptor α (RARA) fusion is hypothesized to serve a vital role in the pathogenesis of acute promyelocytic leukemia (APL), which results from a reciprocal translocation between chromosomes 15 and 17, t(15;17)(q24;q21). 30680014

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE This is the case for Acute Promyelocytic Leukemias (APL) where SUMOylation, and subsequent destruction, of the PML-RARα fusion oncoprotein are triggered by arsenic trioxide, which is used as front-line therapy in combination with retinoic acid to cure APL patients. 31405039

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE Conversely, S100A3 knockdown in PML-RARα<sup>+</sup> APL and PML-RARα<sup>-</sup> AML cells reduces the amounts of RARα/PML-RARα and increases basal and ATRA-induced differentiation. 30532072

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE External quality assessment for PML-RARα detection in acute promyelocytic leukemia: Findings and summary. 31131502

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE Droplet digital PCR for quantification of PML-RARα in acute promyelocytic leukemia: a comprehensive comparison with real-time PCR. 30617397

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE 2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia. 30076181

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 GeneticVariation BEFREE Additionally, fewer than 5% of APL cases have another partner gene fused to the RARA gene. 31350930

2019

Entrez Id: 5914
Gene Symbol: RARA
RARA
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.700 Biomarker BEFREE Arsenic trioxide (ATO) is another anti-cancer agent that promotes autophagy-dependent clearance of promyelocytic leukemia retinoic acid receptor alpha gene (PML-RARα) in APL cells. 31330838

2019