Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE To conclude, systemic p16 peptide administration decreased lung tumor development in a mouse metastatic BT model without severe adverse events, as assessed by blood analyses and histological evaluation. 30655885

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE <b>Patients & methods:</b> Lung tumor tissue microarray (n = 163), immunohistochemical study of p16 and p53, and HPV <i>in-situ</i> hybridization were analyzed. 31157548

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations. 26674347

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification BEFREE In multivariate analysis, p16 hypermethylation was more prevalent in lung tumours from male than female patients (P = 0.018) and in squamous cell carcinomas than in adenocarcinomas (P = 0.025). 22217548

2012

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE Western blot analysis showed that stromal cells of lung tumours were characterised by a statistically significantly lower expression level of the p16 protein as compared with that in normal lung stromal cells. 20407446

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat. 20135361

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE Our analyses revealed a high frequency of aberrant hypermethylation of MTHFR, RASSF1A, and CDKN2A in lung tumors as compared with control blood samples, whereas no significant increase in methylation levels of GSTP1 and CDH1 was observed, consistent with the notion that aberrant DNA methylation occurs in a tumor-specific and gene-specific manner. 19118009

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker RGD Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. 19409458

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human DNA methylation markers and early recurrence in stage I lung cancer. 18337602

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Quantitative p16 and ESR1 methylation in the peripheral blood of patients with non-small cell lung cancer. 18949413

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker LHGDN Retrospective analysis of the prognostic role of p16 protein inactivation in plasma in patients with locally advanced non-small cell lung cancer. 18243403

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE The formation of lung tumors by these chemicals involved mutations in the K-ras cancer gene and loss of heterozygosity in the region of K-ras on distal chromosome 6, while alterations in p53 and p16 were implicated in brain tumorigenesis. 16860786

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker LHGDN Effects of exogenous p16(ink4a) gene on biological behaviors of human lung cancer cells. 17393105

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE To further explore the molecular mechanisms between altered TSGs promoter methylation and overexpression of DNMTs protein, we performed a tissue chromatin-immunoprecipitation polymerase chain reaction assay for lung tumors and showed that the methylated FHIT, p16(INK4a) and RARbeta promoters were bound by both DNMT protein and methyl-CpG-binding protein 2. 17140695

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation LHGDN Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. 17575133

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE H1299 lung cancer cells, lacking Fhit, Wwox, p16(INK4a) and Rassf1a expression due to epigenetic modifications, were used to assess efficacy of epigenetically targeted protocols in suppressing growth of lung tumors, by injection of 5-aza-2-deoxycytidine (AZA) and trichostatin A (TSA) in nude mice with established H1299 tumors. 17019711

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker LHGDN Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. 17936562

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE Based on the concordance of biomarkers in lung tumours and corresponding sputum, and the low prevalence in cancer-free individuals, we selected seven markers for a nested case-control study: microsatellite instability of D9S942; loss of heterozygosity of D9S286, D9S942, GATA49D12, and D13S170; and methylation of p16INK4a and RARbeta. 17973238

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients. 16222700

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers. 16533425

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE Moreover, and consistent with p14ARF being a determinant of CHK2 phosphorylation in lung carcinogenesis, a strong correlation between p14ARF and phospho-CHK2 (Thr68) protein expression is observed in human lung tumors (P < 0.00006). 16705183

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE A subset of the lung tumors (8/28) displayed reduced levels of p16(Ink4a) expression (P = 0.02). 16482519

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer. 16828922

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers. 16533425

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 PosttranslationalModification LHGDN Moreover, the reverse correlation between p16INK4a immunostaining and p16INK4a promoter hypermethylation was also only observed in nonsmoking female lung tumors. 15455389

2005