Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker BEFREE This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because <i>Ipo11</i> mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor. 28193699

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker CTD_human The ISG15-specific protease USP18 regulates stability of PTEN. 27980214

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker BEFREE These findings explain the correlation between loss of IPO11 and PTEN protein in human lung tumors. 28193700

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker BEFREE To investigate the effect of olaparib and cisplatin on PTEN-deficient lung tumors, two EGFR-mutant (deletion in exon19) non-small cell lung cancer (NSCLC) cell lines, PC-9 (PTEN wild-type) and H1650 (PTEN loss), were used. 23239809

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker BEFREE To explore the spectrum of driver mutations among lung cancer tissues from never smokers, specifically in a population where high lung cancer rates have been attributed to indoor air pollution from domestic coal use, multiplexed assays were used to detect >40 point mutations, insertions, and deletions (EGFR, KRAS, BRAF, HER2, NRAS, PIK3CA, MEK1, AKT1, and PTEN) among the lung tumors of confirmed never smoking females from Xuanwei, China [32 adenocarcinomas (ADCs), 7 squamous cell carcinomas (SCCs), 1 adenosquamous carcinoma (ADSC)]. 24055406

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker CTD_human Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. 17909629

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 AlteredExpression LHGDN PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. 17912443

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 AlteredExpression LHGDN Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. 15802268

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker BEFREE To determine whether SP-A aberrations are lung cancer-specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. 16061856

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker BEFREE Mutations of this gene are common in brain, prostate, endometrial, and gastric cancers but occur rarely in non-small-cell lung cancer (NSCLC), although the PTEN protein is often lost in lung tumors. 16084946

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 PosttranslationalModification LHGDN RRM1-induced metastasis suppression through PTEN-regulated pathways. 12687015

2003

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 GeneticVariation BEFREE All the lung tumors with PTEN/MMAC1/TEP1 mutations were homozygous for the mutant alleles. 9598803

1998

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker HPO

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 GenomicAlterations CGI

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 CausalMutation CGI