Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE Role of 3' repressor sequences of p53 in anti-cancer drug sensitivity of human lung tumor cells. 27591972

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE Genetic examination revealed mutations in EGFR and p53 that were of the same type as the lung tumor, leading to the final diagnosis of the femoral mass as a sarcomatous transformation of metastatic lung adenocarcinoma. 26045851

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Therapeutic CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE A total of 189 lung cancer patients were enrolled to determine nickel levels in tumor-adjacent normal lung tissues and p53 mutation status in lung tumors through atomic absorption spectrometry and direct sequencing, respectively. 24711049

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE In this work, we found that PNAS-4 expression in lung tumor tissues is significantly lower than that in adjacent lung tissues; its expression is significantly increased in A549 cells after exposure to cisplatin, methyl methane sulfonate, and mitomycin; and its overexpression induces S phase arrest and apoptosis in A549 (p53 WT), NCI-H460 (p53 WT), H526 (p53 mutation), and Calu-1 (p53(-/-)) lung cancer cells, leading to proliferation inhibition irrespective of their p53 status. 25918161

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE In addition, a positive correlation between the expression of p53 and Tpt1 only existed in normal lung tissues, not in lung tumors. 24067374

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE Genomic characterization of recurrent breast and lung tumors developed over the course of 10 years in a 29-year-old patient with a germline TP53 mutation (Li-Fraumeni Syndrome) identified oncogenic alterations in the HER2 and EGFR genes across all tumors, including HER2 amplifications, an EGFR-exon 20 insertion, and the first-in-humans HER2V659E mutation showing a phenotypic convergent evolution toward HER2 and EGFR alterations. 23950206

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE Our preliminary data showed that LKB1 loss was associated with p53 mutation in lung tumors from Taiwanese adenocarcinoma patients and p53 transcription is directly regulated by NKX2-1. 23995788

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE Coexpression of siRNA-resistant wild-type, but not mutant, human p53 rescued both IL-17-mediated migration and MMP-9 mRNA induction in p53 knockdown lung tumor cells. 25038189

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE In conclusion, we demonstrated that a polyclonal antibody raised against mouse p53 could cross-react with human glucosidase II, which was found to be frequently overexpressed in human lung tumor tissues and exhibited a stress response similar to p53. 24008518

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE We demonstrate proof of concept of this approach by inducing bioluminescent lung tumours in conditional Kras and p53 mice. 24307564

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE Furthermore, at the gene level, we identified a rare G>C mutation in TP53, which is uncommon in lung tumors in general (<0.2%) but has been observed in other arsenic-related malignancies. 24128716

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker BEFREE Herein, we review the epidemiologic connection between tobacco exposure and cancer, the molecular basis of p53 mutation in lung cancer, and the normal molecular and cellular roles of p53 that are abrogated during lung tumor development and progression as defined by in vitro and in vivo studies. 24442106

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE We found that four of the variants (rs3829787, rs3841324, rs588765 and rs3743073) were associated with differential levels of genetic alterations measured as the levels of hydrophobic DNA adducts in the adjacent histologically normal tissue of the lung cancer patients and as TP53 mutations in their lung tumors. 23011884

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE The combination of HPV 16/18 E6 status and p53 codon72 polymorphism in lung tumors is an important biologic and prognostic parameter. 23522190

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE Human papillomavirus (HPV) 16/18 E6 oncoprotein is expressed in lung tumors and is associated with p53 inactivation. 22982189

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE Further analysis of the expression pattern of 14-3-3 gamma in lung tumors showed a correlation with p53 mutations suggesting that p53 might suppress 14-3-3 gamma expression. 21867493

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE These findings were validated in breast and lung tumor samples with TP53 mutations. 21616106

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE In adjacent histologically normal lung from lung cancer patients (n = 120), low levels of DNA methylation of the CYP1A1 enhancer were related to high levels of smoking-induced hydrophobic DNA adduct (p < 0.03), and to the presence of TP53 or K-ras mutations in the corresponding lung tumors (p < 0.03). 22213191

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 AlteredExpression BEFREE By qRT-PCR, RBBP6 mRNA expression was 1.6 fold higher, whereas p53 mRNA expression was 2.9 fold lower in lung tumors compared with normal lung tissue. 21676486

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE Previous studies indicate that these adducts might be involved in producing mutations in the p53 tumor suppressor gene, as observed in lung tumors in smokers, but there are only limited published data comparing acrolein-DNA adducts in smokers and nonsmokers. 21090699

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE The triciribine/tipifarnib synergistic effects are seen with several cancer cell lines including those from breast, leukemia, multiple myeloma and lung tumors with different genetic alterations such as K-Ras, B-Raf, PI3K (phosphoinositide 3-kinase), p53 and pRb mutations, PTEN, pRB and Ink4a deletions, and ErbB receptor overexpression. 21536547

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 GeneticVariation BEFREE These findings were validated in breast and lung tumor samples with TP53 mutations. 21094160

2011