Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Advanced GC data suggested that early mutations (APC and TP53) may affect the potential of cancerous progression from D/IEN. 30474112

2019

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Our results also showed that hsa-miR-29c-5p is an important regulator of CDC42 and DNMT3A genes in the intestinal subtype gastric cancer and hsa-miR-135b-5p regulates the APC gene in both intestinal and diffuse subtypes of GC. 30376837

2018

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 PosttranslationalModification BEFREE Serum RASSF1A and APC promoter hypermethylation is a frequent epigenetic event in patients with early operable gastric cancer. 26073472

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently detected in the intestinal phenotype of GC, whereas CDH1 gene mutation, microsatellite instability and DNA hypermethylation of MLH1 are common events in the gastric phenotype of GC. 26033320

2015

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Losses of a CNV at 5q22, especially in the DNA region surrounding APC-exon 9, may be associated with a higher risk of gastric cancer. 25210923

2014

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE The frequencies in GC serum were 30.67% for APC, 34.67% for WIF-1, 37.33% for RUNX-3, 29.33% for DLC-1, 33.33% for SFRP-1, 32% for DKK, and 26.67% for E-cad. 23049225

2012

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Activation of Wnt signaling without mutation of β-catenin or APC occurs frequently in human gastric cancers. 22246241

2012

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE In contrast to colon and gastric cancers, no APC nonsense mutations were found in small bowel adenocarcinoma. 20179237

2010

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Five different classes of methylation behaviors were found: (1) genes methylated in GC only (GSTP1 and RASSF1A); (2) genes showing low methylation frequency (<12%) in CG, IM, and GA, but significantly higher methylation frequency in GC (COX-2, hMLH1, and p16); (3) a gene with low and similar methylation frequency (8.8-21.3%) in four-step lesions (MGMT); (4) genes with high and similar methylation frequency (53-85%) in four-step lesions (APC and E-cadherin); and (5) genes showing an increasing tendency with or without fluctuation of the methylation frequency along the progression (DAP-kinase, p14, THBS1, and TIMP3). 12746473

2003

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Five different classes of methylation behaviors were found: (a). genes methylated in GC only (GSTP1 and RASSF1A), (b). genes showing low methylation frequency (<12%) in CG, IM, and gastric adenoma (GA) but significantly higher methylation frequency in GC (COX-2, hMLH1, p16), (c). a gene with low and similar methylation frequency (8.8-21.3%) in four-step lesions (MGMT), (d). genes with high and similar methylation frequency (53-85%) in four-step lesions (APC and E-cadherin), and (e). genes showing an increasing tendency with or without fluctuation of the methylation frequency along the progression (DAP-kinase, p14, THBS1, and TIMP-3). 12695555

2003

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE APC mutation is involved in carcinogenesis of intestinal type of gastric cancer and is independent of MSI phenotype but related to the LOH pathway in gastric cancer. 12378616

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE APC and beta-catenin gene mutations are also present primarily in intestinal-type gastric cancers. 11756228

2002

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Gastric cancer showed frequent genetic alterations of the APC gene, and the risk for gastric cancer in familial adenomatosus polyposis patients is 10 times higher than that in the general population. 10485468

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability. 10605402

1999

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Mutation of the hMSH6 gene was observed in a subset of gastric cancers (4/30, 13.3%), but was not associated with P53 overexpression or APC gene mutation. 9808525

1998

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE These data suggest that allelic deletion of the p53 gene in intestinal-type gastric carcinoma predicts the invasive potential of mucosal cancer, and that inactivation of the APC gene plays a role in the genetic tumorigenesis of both intestinal and diffuse types of gastric cancer. 9990480

1998

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Infrequent alterations of the APC and MCC genes in gastric cancers from British patients. 8855982

1996

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Our results suggest that there are distinct differences in the molecular pathogenesis of gastric and pancreatic cancer and that abnormalities of APC and MCC may be involved particularly in the diffuse type of gastric cancer. 8406987

1993

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Since some gastric cancers are considered to originate from the intestinal metaplasia, it is likely that the adenomatous polyposis coli (APC) gene, the mutation of which causes adenomatous polyps in the colon, is associated with carcinogenesis of gastric cancer. 1317264

1992

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE We searched for somatic mutations of the adenomatous polyposis coli (APC) gene in DNA samples isolated from 57 sporadic gastric cancers, by means of a ribonuclease (RNase) protection analysis coupled with DNA amplification by the polymerase chain reaction (PCR). 1338691

1992

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker HPO

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker CTD_human

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 CausalMutation CGI