Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488

2018

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE The rarity of HRAS and KRAS Q61R mutants in malignant melanoma let previous investigations erroneously conclude that SP174 is specific for NRAS Q61R-mutant protein. 29206715

2018

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Few studies have focused on the transcriptional level of RAS isoforms (KRAS, NRAS, and HRAS) in cutaneous melanoma. 29349077

2017

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE Integrative sequencing of cutaneous melanoma metastases using different sequencing platforms revealed a new somatic point mutation in HRAS and a structural rearrangement affecting CDKN2C (a CDK4 inhibitor). 23174022

2013

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population. 22618666

2012

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE The second patient had malignant melanoma, in which we identified a somatic point mutation in HRAS and a structural rearrangement affecting CDKN2C. 22133722

2011

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE This was in accordance with the literature: review showed that no HRAS mutations had so far been reported in Spitzoid melanomas. 20871217

2010

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE We showed that HRAS activation cooperates with Pten+/- and Ink4a/Arf-/- to increase melanoma penetrance and promote metastasis. 20711233

2010

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE To look for evidence of progression from Spitz naevi to spitzoid melanoma, HRAS was analysed in 21 spitzoid melanomas, with no mutations identified. 19438459

2009

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE We have established a model of melanoma progression in zebrafish through the generation of transgenic lines specifically expressing oncogenic human HRAS in the melanocytic lineage. 20047469

2009

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE The impact of HRAS on the UPR was selective, as it was poorly induced by activated NRAS (more frequently mutated in melanoma than HRAS). 16964246

2006

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE We have investigated 37 sporadic malignant melanomas (15 primary cutaneous melanomas and 22 melanoma metastases) and 6 melanoma cell lines for mutations in the 3 Ras genes NRAS, KRAS and HRAS. 14961576

2004

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE HRAS activation by either mutation or copy number increase alone could explain several of the histological features that overlap with those of melanoma. 10980135

2000

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Loci from these chromosome regions were chosen because of cytogenetic abnormalities reported in melanoma (1p, 6q, 9p), location of common oncogenes (11p-HRAS, 17p-TP53), or use in other MIN studies (5q, 18q). 9666803

1998

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE No significant differences were detected in the c-neu and Ha-ras mRNA levels in naevi and melanomas. 1686168

1991

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE Nodular melanoma, epithelioid cell type melanoma, and deeply invading melanoma revealed higher reactivity with anti-p21ras monoclonal antibody than the other types. 2664010

1989

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE The results of these studies are (1) 24% of cultured malignant melanomas have activated ras genes, with N-ras being activated ten times as frequently as Harvey (Ha)-ras. 2682463

1989

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE c-Ha-ras-1 alleles in bladder cancer, Wilms' tumour and malignant melanoma. 2892780

1988

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE These results imply that hereditary predisposition to melanoma is associated with genes other than the Ha-ras-1 locus, contradicting the original suggestion of Krontiris et al., made on the basis of either an inadequate sample size or other misleading experimental factors. 2879249

1987

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE However, the analysis of the same DNAs for a different polymorphism based on the presence of additional TaqI sites in the variable tandem repeat region of HRAS1 showed that the total frequency of a group of allelic variants, named Tp, was significantly higher in melanoma patients than in normal donors. 2894003

1987

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE Amplification of activated c-Ha-ras-1 in human melanoma. 3928549

1985

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 Biomarker BEFREE An SstI fragment of 2.9 kb carrying all four coding exons of the human melanoma c-Ha-ras-1 oncogene could not transform mouse NIH 3T3 cells. 3932274

1985

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 AlteredExpression BEFREE The activation of c-Ha-ras and N-ras has been described in some cell lines derived from cases of human malignant melanoma. 6090953

1984

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0025202
Disease: melanoma
melanoma
0.800 GeneticVariation BEFREE Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. 6087347

1984