Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. 31836388

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE In this study, we used wild-type (A375) and mutant p53 (MeWo) melanoma cell lines to assess the regulation of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD) by mutant p53. 31812668

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE In conclusion, all examined genes may have implications in melanoma development and functional inactivity of TP53. 31462745

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE Early results from our group indicated that 4-nerolidylcatechol (4-NC), a catechol compound extracted from Pothomorphe umbellata, induces DNA damage, ROS production, increased p53 expression culminating in apoptosis in melanoma but with no data regarding the 4-NC effects in cells resistant to BRAFi or MEKi. 30550954

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE TP53 mutations were commonly (50%) observed among the carcinoma cases, while other mutations were characteristic for the primary cancers (VHL in renal, BRCA1 in the fallopian tube, and BRAF in melanomas). 31517642

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Because the main feature of melanoma is the resistance to most chemotherapeutics, our studies suggest that the 8i tetra-substituted pyrrole derivative, restoring p53 functions and its transcriptional activities, may have potential application, at least as adjuvant, in the treatment of human melanoma. 31240514

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE The protein levels of p53 and p21 increased upon the treatment with albendazole and fenbendazole, indicating activation of the p53-p21 pathway, while the levels of Mdm2 and MdmX decreased in melanoma and breast cancer cells overexpressing these proteins. 31181622

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Although neither of these two genes have been previously associated with sarcoma, ABCB5 has been shown to share clinical drug resistance associations with melanoma and leukaemia and C16orf96 shares regulatory elements with genes that are involved with TNF-alpha mediated apoptosis in a p53/TP53-dependent manner. 31053105

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE Indeed, cell line experiments revealed a diminished IFN-ɣ-induced PD-L1 expression upon p53 knockdown in both wildtype and TP53-mutated melanoma cells, which was not the case when p53 wildtype protein was rendered transcriptionally inactive or by ectopic expression of p53<sup>L22Q,W23S</sup>, a transcriptionally-impaired variant, in TP53-wt cells. 31506076

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE In this review, we will focus on two approaches that are under evaluating for targeting melanoma: (1) against genome instability by p53 network restoration and (2) disrupt cancer proteome by chaperone inhibition. 30778775

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE We demonstrate that melanomas with high levels of DNp73, a cancer-specific variant of the p53 family member p73 and driver of melanoma progression show, in contrast to their less-aggressive low-DNp73 counterparts, hypopigmentation in vivo. 30445206

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE We observed that mutations detected in tumor samples involving genes related to melanoma pathogenesis (TP53, PIK3CA, FGFR3, ATF1, KIT, HRAS and MAP2K2) were present in heterozygosis in the germline status of the patient. 31804055

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE The resistance of melanoma cells to radiotherapy may also be in relation with the constitutive activation of the MAPK pathway and/or with the inactivation of p53 observed in about 90% of melanomas. 31374895

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE TP53 mutations are rare in cutaneous melanoma and hence activation of wild-type p53 is a potential therapeutic strategy in cutaneous melanoma. 29235570

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker CTD_human Considering the antitumor activity of benzothiazolic derivatives, this study aimed to demonstrate the action of benzothiazolic (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-4-nitrophenol (AFN01) against three established human melanoma cell lines that recapitulate the molecular landscape of the disease in terms of its genetic alterations and mutations, such as the TP53, NRAS and B-RAF genes. 29574239

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 PosttranslationalModification BEFREE We found that treatment-induced de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma. 30587121

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE UV-induced mutations in TP53 and CDKN2A are frequent in melanoma. 29374752

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE We then proved that TRPV1 overexpression or its agonist capsaicin treatment inhibited melanoma growth by activating p53 and inducing cell apoptosis. 29580868

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE TP53 has been proved to be associated with cytotoxic T-cell induced apoptosis, however, the association between TP53 and the benefit of immunotherapy in melanoma has not been studied. 29793878

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma. 30577494

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Significantly mutated genes included BRAF, CDKN2A, NRAS and TP53 in cutaneous melanoma, BRAF, NRAS and NF1 in acral melanoma and SF3B1 in mucosal melanoma. 28467829

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE These results add to the understanding of the clinical features associated with TP53 and BRAF<sup>Non-V600</sup> mutations in advanced cutaneous melanoma patients, and they support the rationale for evaluating the prognostic significance of TP53 in other cohorts of melanoma patients.Cancer 2017;123:1372-1381.© 2016 American Cancer Society. 27911979

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Whereas TP53 gene mutations are frequently observed in other cancers, ROS1 mutations are common in melanoma (15%-35%), another neural crest-derived malignancy. 27875628

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation. 28469092

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE In the present study, we first determined whether all three members of the P53 family of transcription factors were found mutated in cutaneous melanomas by retrieving all TP53, TP63 and TP73 mutations from cBioPortal (http://www.cbioportal.org/). 28849221

2017