Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Anti-melanization effects and inhibitory kinetics of tyrosinase of bird's nest fern (Asplenium australasicum) frond extracts on melanoma and human skin. 30639118

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE This molecule is capable of constructing an efficient catalytic redox cycle with tyrosinase and NQO1 in melanoma B16F1 cells to induce selectively the ROS (mainly including hydrogen peroxide, H<sub>2</sub>O<sub>2</sub>) accumulation in the cells, resulting in highly selective suppression of melanoma B16F1 cells over tyrosinase-deficient HeLa and normal L-02 cells. 30458279

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE This work provides further evidence to support that dietary catechols exhibit antimelanoma activity by virtue of their tyrosinase-dependent pro-oxidative role and gives useful information for designing polyphenol-inspired GST inhibitors and sensitizers in chemotherapy against melanoma. 31339696

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Tyrosinase (TYR) which can catalyze the oxidation of catechol is recognized as a significant biomarker of melanocytic lesions, thus developing powerful methods for the determination of TYR activity is highly desirable for the early diagnosis of melanin-related diseases, including melanoma. 30916930

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression BEFREE Thereafter, increasing levels of TYR were recorded in cells that were collected from the skin of melanoma mouse models representing three different stages of tumor growth. 31529964

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE Amelanotic/hypomelanotic melanoma was associated with TYR rs1126809*A/A [OR (CI 95%) 2.7 (1.1-6.8) vs. 1.2 (0.8-1.9)] and PLA2G6 rs11570734*A/A [OR (CI 95%) 3.7 (1.0-13.6) vs. 1.3 (0.9-2.0)]. 30680790

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression BEFREE We carried out herein the screening of a family of cyclic Morita-Baylis-Hillman adducts (MBH) to find out their effects on tyrosinase activity and on melanogenesis in murine melanoma B16F10 cell line. 30476649

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE An alternative approach to impede melanoma progression will be to administer the enzyme tyrosinase (TYR), which converts l-tyr into melanin. 30605301

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Therefore, this study explores whether miR-374 targeting tyrosinase (TYR) affects melanoma and its underlying mechanism. 31207106

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Melanoma is an aggressive malignant tumor that undergoes rapid growth and metastasis in a short time; tyrosinase (TYR) is an important biomarker for melanoma diagnosis as it is over-expressed in melanoma cells. 31384852

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression BEFREE FEPS inhibited mushroom tyrosinase with the half maximal inhibitory concentration (IC<sub>50</sub>) of 16.5 mg/ml and dose-dependently inhibited cellular tyrosinase activity (63.9% at 50 μg/ml, and 83.3% at 100 μg/ml) in the cell-free extract of SK-MEL-5 human melanoma cell and α-melanocytestimulating hormone (α-MSH)-stimulated melanin formation in intact SK-MEL-5 human melanoma cell. 31336432

2019

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE The detection of tyrosinase, a biomarker for melanoma, is of great significance. 29198104

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Tyrosinase, a copper-containing enzyme existing widely in plants, animals and microorganisms, usually serves as an important biomarker in melanoma, and is also related to hyperpigmentation of the skin, melasma, age spots and albinism. 30467562

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE In this study, a fluorescent probe called NBR-AP for detecting tyrosinase (a biomarker of melanoma) has been created by incorporating a hydroxyphenylurea group (as a substrate for the enzyme) onto a fluorescent dye phenoxazine derivative (as an activatable signal reporter). 29975041

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE A series of N-aryl-2-phenyl-hydrazinecarbothioamides have been investigated as possible inhibitors of tyrosinase, an enzyme involved in the development of melanomas. 30118988

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Although radioiodine labeled 4-hydroxyphenylcysteamine, which we previously developed, has good affinity for tyrosinase, an enzyme in the melanin metabolic pathway, image contrast of the melanoma:organ ratios is not sufficiently high for detection of primary melanoma and metastases at early injection times. 29413752

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE The <i>in vivo</i> expression of multiple chimeric MHC class I receptors allows a simultaneous presentation of several melanoma-associated shared antigens tyrosinase related protein (TRP)-1, tyrosinase, human glycoprotein 100 and TRP-2. 29900058

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases. 29383286

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Bioluminescence imaging results show that TYR-LH<sub>2</sub> is fully competent for monitoring the dynamic changes of TYR in living cells and model animals and possesses the capability of discriminating melanocytes from other cell lines, thus offering a promising approach for investigation and diagnosis of melanoma cancer and other TYR-related diseases in vivo. 29943981

2018

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation BEFREE In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. 28583798

2017

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression BEFREE Furthermore, the derivatives 3l and 3m showed cell selectivity with significant cytotoxic effects (IC<sub>50</sub> values of 46-65μM) against melanoma cell lines with tyrosinase overexpression MNT-1 and B16F10. 28602669

2017

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression BEFREE G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma. 27378491

2017

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression BEFREE Reduction of tyrosinase activity has been targeted for preventing and healing hyperpigmentation of skin, such as melanoma and age related spots. 28017864

2017

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation GWASCAT Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. 28212542

2017

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker BEFREE Objectives A xenogeneic human tyrosinase DNA vaccine was developed for treatment of dogs with oral malignant melanoma (Oncept; Merial). 26685147

2017