×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
BEFREE
The hereditary cancer syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and succinate dehydrogenase-related hereditary paraganglioma and pheochromocytoma (SDH PGL/PCC) are linked to germline loss-of-function mutations in genes encoding the Krebs cycle enzymes fumarate hydratase and succinate dehydrogenase, thus leading to elevated levels of fumarate and succinate, respectively<sup>1-3</sup>.
30013182
2018
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB , SDHC and SDHD .
29386252
2018
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
The penetrance of paraganglioma and pheochromocytoma in SDHB germline mutation carriers.
28503760
2018
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
The penetrance of paraganglioma and pheochromocytoma in SDHB germline mutation carriers.
28503760
2018
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
The phenotype of SDHB germline mutation carriers: a nationwide study.
28490599
2017
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
27604842
2017
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Calculating the optimal surveillance for head and neck paraganglioma in SDHB-mutation carriers.
27573198
2017
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
SDHB-related pheochromocytoma and paraganglioma penetrance and genotype-phenotype correlations.
28374168
2017
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
The phenotype of SDHB germline mutation carriers: a nationwide study.
28490599
2017
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
A Duodenal SDH-Deficient Gastrointestinal Stromal Tumor in a Patient With a Germline SDHB Mutation.
28324028
2017
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
SDHB-related pheochromocytoma and paraganglioma penetrance and genotype-phenotype correlations.
28374168
2017
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
A SDHC Founder Mutation Causes Paragangliomas (PGLs) in the French Canadians: New Insights on the SDHC-Related PGL.
27700540
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Attention Deficit Hyperactivity Disorder in Pediatric Patients with Pheochromocytoma and Paraganglioma.
27171833
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy.
26642834
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
Novel SDHB and TMEM127 Mutations in Patients with Pheochromocytoma/Paraganglioma Syndrome.
26960314
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.
26719882
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Rapid-sequence MRI for long-term surveillance for paraganglioma and phaeochromocytoma in patients with succinate dehydrogenase mutations.
27634942
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Mediastinal paragangliomas related to SDHx gene mutations.
27785149
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma/paraganglioma patients.
27279923
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Sporadic paraganglioma caused by de novo SDHB mutations in a 6-year-old girl.
26283294
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Carney triad can be (rarely) associated with germline succinate dehydrogenase defects.
26173966
2016
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
Association of urinary bladder paragangliomas with germline mutations in the SDHB and VHL genes.
25683602
2015
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.
25394176
2015
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Structural and functional consequences of succinate dehydrogenase subunit B mutations.
25972245
2015
×
Entrez Id:
6390
Gene Symbol:
SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
15 YEARS OF PARAGANGLIOMA: Clinical manifestations of paraganglioma syndromes types 1-5.
26273102
2015