Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 29335545

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. 28319090

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE KLF5 loss enhances tumor angiogenesis by attenuating PI3K/AKT signaling and subsequent accumulation of HIF1α in PTEN deficient prostate tumors. 25896712

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE PTEN loss in Gleason score 6 biopsies identifies a subset of prostate tumors at increased risk of upgrading at radical prostatectomy. 24993522

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo. 25007053

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE The expression of PTEN, NKX3.1, SPINK1, DD3, and AMACR genes was significantly deregulated in prostate tumor samples (p range 0.000-0.044). 24985972

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Met was amplified in 67% of prostate tumors from Pten p53 prostate conditional null mice and in approximately 30% of metastatic human prostate cancer specimens, often in association with loss of PTEN and TP53. 25381262

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Here, we show that AKT2 is exclusively required for PTEN-deficient prostate tumor spheroid maintenance, whereas AKT1 is dispensable. shRNA silencing of AKT2 but not AKT1 promotes regression of prostate cancer xenografts. 24838891

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE We have quantitatively analyzed the mRNA levels of TMPRSS2-ERG, ERG, PTEN, and AR (n = 83), as well as ERG immunostaining (n = 78) in a series of prostate tumors. 25939480

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Here we show that at the onset of senescence, PTEN null prostate tumours in mice are massively infiltrated by a population of CD11b(+)Gr-1(+) myeloid cells that protect a fraction of proliferating tumour cells from senescence, thus sustaining tumour growth. 25156255

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 GeneticVariation BEFREE Using the conditional PTEN deletion mouse model, we previously reported that survivin levels increase with prostate tumor growth. 23936028

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Behavioral stress inhibited apoptosis and delayed prostate tumor involution both in phosphatase and tensin homolog-deficient (PTEN-deficient) prostate cancer xenografts treated with PI3K inhibitor and in prostate tumors of mice with prostate-restricted expression of c-MYC (Hi-Myc mice) subjected to androgen ablation therapy with bicalutamide. 23348742

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE IGF-IR expression positively correlates with PTEN and inversely correlates with NRP2 in prostate tumors. 22777769

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. 23248098

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Fibroblast growth factor and ornithine decarboxylase 5'UTRs enable preferential expression in human prostate cancer cells and in prostate tumors of PTEN(-/-) transgenic mice. 21921943

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. 22581815

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE PTEN protein loss was then assessed on 376 prostate tumor samples, and PTEN FISH or high resolution single nucleotide polymorphism microarray analysis was done on a subset of these cases. 21878536

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. 22610119

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines. 20729295

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells. 21456062

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human Resveratrol and prostate cancer: promising role for microRNAs. 21714127

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE In this study, we show that patients who develop prostate tumors with low levels of PTEN and high levels of HER2/3 have a poor prognosis. 21930937

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE Retroviral expression of constitutively active Notch-1 in human prostate tumor cell lines resulted in increased PTEN gene expression. 19479935

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker CTD_human The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision. 19081794

2009