Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker BEFREE Thus, clear evidence for regulating miRNA processing and VEGF output by intrinsic PGE-2 production provides a means to distinguish between aggressive and indolent prostate tumors and suggests a potential target for controlling tumor progression. 27322147

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker BEFREE These inhibitory effects were accompanied by mechanistic down-regulation of the protein levels of inflammatory enzymes (inducible nitric oxide synthase, iNOS and cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2 and MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), and proliferative molecules, as well as by the induction of apoptosis in prostate tumors. 23673480

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression BEFREE One study in nude mice injected via tail vein with hepatocarcinoma SK-Hep-1 cells showed that BC decreases the plasma VEGF level, whereas the other study in nude mice injected subcutaneously with prostate tumor PC-3 cells showed that BC increases the plasma VEGF level. 22469593

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab. 20052738

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer. 19089921

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression BEFREE Nevirapine induced extensive reprogramming of gene expression in vitro with up-regulation of genes that might be silenced during prostate tumor progression (i.e., K18, PSA and androgen receptor) and down-regulation of genes involved in the progression toward an androgen-independent phenotype (i.e., K5, EGFR1, EGF and VEGF-A). 19152342

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway. 18615482

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker BEFREE A statistically significant correlation between expression of cyclin A1 and of MMP2, MMP9, and VEGF was observed in prostate tumors from 482 patients (P values from Spearman rank correlation tests < .001). 18612129

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Human telomerase reverse transcriptase expression correlates with vascular endothelial growth factor-promoted tumor cell proliferation in prostate cancer. 18437586

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. 18240292

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. 18486981

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker BEFREE Prostate tumors showed a significant increase in the percentage of VEGF(121) and decreases in VEGF(165) (p < 0.01) and VEGF(189) (p < 0.05). 17278099

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker BEFREE These observations support the hypothesis that genistein may inhibit prostate tumor angiogenesis through the suppression of VEGF-mediated autocrine and paracrine signaling pathways between tumor cells and vascular endothelial cells. 17142033

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Plasma levels and expression of vascular endothelial growth factor-A in human localized prostate cancer. 17549360

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker BEFREE Interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) are two cytokines promoting prostate tumor growth and angiogenesis. 16530725

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome. 16908180

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker CTD_human Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression. 16606632

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia. 16820871

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells. 16826426

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. 16278385

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Vascular endothelial growth factor (VEGF), its receptors (VEGFRs), and alpha5beta1 integrin were expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor. 15500293

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression BEFREE Vascular endothelial growth factor (VEGF), its receptors (VEGFRs), and alpha5beta1 integrin were expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor. 15500293

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: expression of lymphangiogenic markers is associated with advanced-stage disease. 15701844

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF). 15905202

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer. 16007189

2005