Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Kaposi's Sarcoma-associated Herpesvirus Viral Interleukin 6 Signaling Upregulates Integrin Beta 3 Levels and is Dependent on STAT3. 31801855

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression BEFREE Detectable KSHV VL and elevated IL-6 levels are present in a subset of children with KS. 30204240

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Viral IL-6 is also considered to contribute significantly to HHV-8-associated pathogenesis, since vIL-6 can promote cell proliferation, cell survival, and angiogenesis that are characteristic of HHV-8-associated Kaposi's sarcoma, PEL and multicentric Castleman's disease (MCD), in addition to proinflammatory activities observed in MCD-like "Kaposi's sarcoma-associated herpesvirus-induced cytokine syndrome." 30541844

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 GeneticVariation BEFREE The Kaposi's sarcoma-associated herpesvirus viral interleukin 6 gene affects metastasis and expression of B cell markers in a murine xenograft model. 30265712

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08). 29381560

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression BEFREE Among downstream genes, two specific metalloproteases, ADAMTS1 and 9, are strongly expressed in AIDS-KS tissues and contribute to KSHV-infected endothelial cell invasiveness through up-regulation of IL-6 and VEGF. 26675551

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling. 27166260

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) promotes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. 24198402

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression BEFREE Expression of the viral interleukin-6 homolog from Kaposi sarcoma-associated herpesvirus is also sufficient to induce significant D6 upregulation both in vitro and in vivo, and Kaposi sarcoma and primary effusion lymphoma cells demonstrate high levels of D6 expression. 23479571

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation. 21984125

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies. 21767154

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells. 19955303

2010

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. 17483315

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression BEFREE Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6. 14672670

2004

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 GeneticVariation BEFREE In addition to the HHV-8 infection, the interleukin-6 promoter polymorphism G-174C is associated with a risk of development of KS in renal transplant recipients. 15154666

2004

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression BEFREE Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways. 12776188

2003

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression LHGDN Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. 12176919

2002

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression BEFREE Several groups have reported that vIL-6 is expressed from the HHV-8 genome at higher levels in PEL and MCD lesions than in KS lesions. 12134031

2002

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression BEFREE Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. 12176919

2002

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE IL-4, a cytokine with pleiotropic effects, suppresses IL-6 in vivo and modestly inhibits AIDS-KS-derived cells in vitro. 12513914

2002

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE The detection of vIL-6--positive lymphoid cells in bone marrow suggests a homing for HHV-8--infected elements in this tissue. 11274637

2001

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of Kaposi's sarcoma and lymphoid cells of multicentric Castleman's disease. 11172301

2001

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Preincubation with recombinant human IL-6 or OSM sensitized KS in a dose dependent manner. 11380243

2001

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. 11264189

2001

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker BEFREE The genome of human herpes virus 8, which is associated with Kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of IL-6. 10779772

2000