Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0036420
Disease: Localized scleroderma
Localized scleroderma
0.020 Biomarker BEFREE Although developmental origins have been hypothesized, evidence points to LS as a systemic autoimmune disorder, as there is a strong correlation to family history of autoimmune disease, the presence of shared HLA types with rheumatoid arthritis, high frequency of auto-antibodies, and elevated circulating chemokines and cytokines associated with T-helper cell, IFNγ, and other inflammatory pathways. 31114575

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0036420
Disease: Localized scleroderma
Localized scleroderma
0.020 AlteredExpression BEFREE The effects of interferon-alpha and interferon-gamma on collagen synthesis and mRNA levels of type I and type III procollagens were studied in skin fibroblasts cultured from affected and unaffected skin sites of two patients with localized scleroderma (morphea). 3122841

1988