Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Furthermore, morin was able to down regulate the levels of inflammatory and apoptotic markers such as nuclear factor kappa B (NF-κB), neuronal nitric oxide synthase (nNOS), tumor necrosis factor-α (TNF-α), p53, cysteine aspartate specific protease-3 (caspase-3) and B-cell lymphoma-2 (Bcl-2). 31722249

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Meanwhile, ACART increased the expression of the B cell lymphoma 2 (Bcl-2) and suppressed the expression of Bcl-2-associated X (Bax) and cytochrome-C (Cyt-C). 31749326

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Compound 7a notably inhibited the expression and activity of PIM kinases, as evidenced by reduced B‑cell lymphoma‑2 (Bcl‑2)‑associated death promoter phosphorylation at Ser112. 31789392

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE After 30 min of ischemia and 120 min of reperfusion, cardiac function, infarct size, cardiac marker enzymes, antioxidative parameters, inflammatory factors, histopathological changes, cardiomyocyte apoptosis, and B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein and caspase‑3 expression were determined using a multi‑channel physiological recording system, nitrotetrazolium blue chloride, biochemical kits, radioimmunoassay kits, hematoxylin and eosin, terminal deoxynucleotidyl‑transferase‑mediated dUTP nick end labeling assay, immunohistochemistry and reverse transcription‑quantitative PCR, respectively. 31789417

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE As a result, we observed higher level of XIST and Smurf1, but lower level of miR-27a in SCI rats and lipopolysaccharide (LPS)-induced primary microglial cells. in vitro, LPS induced SCI microglia cells as described by decreased cell viability and B cell lymphoma 2 (Bcl-2) expression, and increased cell apoptosis rate, Bax and cleaved caspase 3 levels, and tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) secretions. in vivo, a T10 laminectomy caused SCI rats as evidenced by decreased Basso-Beattie-Bresnahan Locomotor Rating Scale (BBB) score and induced expression of Bax, cleaved caspase 3, TNF-α and IL-6. 31778769

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE <i>MYC/BCL2</i> DHL, <i>MYC/BCL6</i> DHL and MYC/BCL2 DEL are an aggressive B cell lymphoma and patients have a poor prognosis. 31615842

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Western blot analysis was used to investigate the effect of DPM on B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cleaved caspase-3. 31553997

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE The levels of Shrm4, GABA<sub>B1</sub>, Bcl-2-associated protein x (Bax), B cell lymphoma 2 (Bcl-2), cleaved Caspase-3, microtubule-associated protein 2 (MAP-2) as well as suppressor of cytokine signaling 2 (SOCS2) were detected to further assess the role of Shrm4 and GABA pathway in NSCs. 31654185

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE The effects of AST were mediated through the downregulation of Bcl-2 associated X, apoptosis regulator (Bax), and cleaved caspase-3 and through the upregulation of B-cell lymphoma 2 (Bcl-2). 31566218

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE We found that ectopic expression of gga-miR-16-5p in DF-1 cells enhanced IBDV-induced apoptosis by directly targeting cellular anti-apoptotic protein B-cell lymphoma-2 (Bcl-2), facilitating IBDV replication in DF-1 cells. 31694944

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE B-cell lymphoma-extra large (Bcl-X<sub>L</sub>) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria. 31734345

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Western blot assay was conducted to examine the protein levels of B-cell lymphoma-2 (Bcl-2), BCL2-Associated X (Bax), matrix metalloprotein 2 (MMP2), MMP9 and PDCD4. 31760170

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Downstream molecular mechanisms, including SRY-box transcription factor 6 (SOX6), extracellular regulated protein kinases (ERK), Cyclin D1, B-cell lymphoma-2 (BCL-2) and BCL2 associated X, apoptosis regulator (BAX), were determined by western blot. 31609809

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE The current study sought to investigate the effect of modified exosome-containing plasmids expressing B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X-protein (Bax) short hairpin RNA (shRNA) on apoptosis and neural functions after TBI. 29762232

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE In addition, modulation of ZEB1 and subsequent change in MRP4 expression correlated with a lower apoptotic response to docetaxel, characterized by lower B-cell lymphoma 2 (Bcl2), high BCL2-associated X protein (Bax), and high active caspase 3 expression. 30880686

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Ocimum basilicum L. significantly decreased testicular levels of nuclear factor-kappa B and B-cell lymphoma-2 (Bcl2)-associated protein X, along with caspase-3 immunohistochemical staining. 31667861

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE The protein levels of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X (Bax), X-linked inhibitor of apoptosis (XIAP), total poly (ADP-ribose) polymerase (PARP), caspase-3 and caspase-8 were examined using western blotting. 31586690

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Furthermore, CP group showed toxic histopathological changes of marked cardiac damage in addition to a significant decrease in total antioxidant capacity (TAC), superoxide dismutase (SOD), eNOS gene expression, and B cell lymphoma 2 (Bcl2) immunoexpression. 31230218

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE CABYR-a/b downregulation suppressed cell proliferation and induced G1-phase arrest via decreasing cyclin D1 and cyclin dependent kinase 4, while promoted apoptosis by reducing B-cell lymphoma 2 (Bcl-2) and increasing Bcl-2-associated death promoter. 31692072

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Diabetes-related physical and biochemical parameters, pancreatic histopathological changes, immunohistochemical staining, quantitative real-time polymerase chain reaction, and western blot were used to measure the expression of apoptosis signal-regulating kinase 1 (ASK1), Jun N-terminal kinase (JNK), Bcl-2 associated X protein (BAX), and B-cell lymphoma-2 (Bcl-2). 31411368

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE The mRNA and protein expression of apoptosis-related genes including Caspase-3, Caspase-9, Caspase-8, Cytochrome-C (Cyt-C), p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein (Bax) were significantly altered in broilers BF. 31841897

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Furthermore, exposure to Pb induced neurodegenerative cognitive impairment in rats, depressed the long-term potentiation (LTP) in the rat brain slices, increased the neuronal intracellular free calcium concentration ([Ca<sup>2+</sup>]i), inhibited the phosphorylation of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII) and cyclic adenosine 3',5'-monophosphate (cAMP) response element binding protein (CREB) as well as the expression of anti-apoptotic protein B-cell lymphoma 2 (Bcl2), and activated the phosphorylation of extracellular regulated protein kinases (Erk) protein both in vitro and in vivo. 31710906

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE The potential protective effects of resveratrol (RES) on the modulation of hepatic biomarkers of apoptosis and survival, p53-Bax axis, and B-cell lymphoma 2 (Bcl-2) in an animal model of paracetamol-induced acute liver injury have not been investigated before. 31554003

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Aβ<sub>25-35</sub> -induced changes in Ca<sup>2+</sup> and B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X (Bax) protein and gene levels in cells were also reversed by genistein. 30450837

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Phase 1 study of lenalidomide plus dose-adjusted EPOCH-R in patients with aggressive B-cell lymphomas with deregulated MYC and BCL2. 30707764

2019