Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Here, we identified a relatively rare mutation leading to a proline to leucine substitution (P152L) in TP53 at the very end of its DNA-binding domain (DBD) in a sample from an Indian oral cancer patient. 31366730

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Identification and characterization of TP53 gene Allele Dropout in Li-Fraumeni syndrome and Oral cancer cohorts. 30076369

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE In contrast, LOH at 3p14 (<i>P </i>= 0.0241), 17p13 (<i>P </i>= 0.0348) and TP53 (<i>P </i>= 0.004) were associated with oral cancer development in the classical subtype only. 30524889

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo. 29923573

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner. 29366881

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer. 30116199

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients. 28459200

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE The combination of vorinostat and AZD1775 inhibits tumor growth and angiogenesis <i>in vivo</i> in an orthotopic mouse model of oral cancer and prolongs animal survival.<b>Conclusions:</b> Vorinostat synergizes with AZD1775 in HNSCC cells with mutant p53 <i>in vitro</i> and <i>in vivo</i> A strategy combining HDAC and WEE1 inhibition deserves further clinical investigation in patients with advanced HNSCC.<i></i>. 28790110

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Gender specific association of TP53 polymorphisms (EX4 215G>C Arg72Pro, IVS3+40-41ins16, and IVS6+62G>A), with risk of oral cancer subtypes and overall survival of the patients. 27532290

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE In oral cancer p53 is mutated, thus we focused on p73; AGG resulted in p73 upregulation and knock down of p73 caused a decrease in AGG-induced apoptosis. 28543759

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE As a result, the proposed PEC biosensor showed excellent analytical performance for both oral cancer (ORVOA 1) gene and p53 gene down to attomolar level. 27003607

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE To identify the prognostic value of c-jun, c-fos, and p53 in oral cancer, we examined the impact of immunohistochemical expression of these markers on tumor progression in 157 oral squamous cell carcinoma (OSCC). 27558649

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 AlteredExpression BEFREE Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression. 26036622

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Neither overall analysis nor stratified analyses detected any obvious evidence of association between p53 Arg72Pro polymorphism and oral cancer susceptibility in all genetic models. 26123760

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE The detection limits, established as 3σ, were estimated to be 0.03 and 0.06 fmol L(-1) for the p53 and oral cancer genes, respectively. 25493424

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE The aim of the present study was to evaluate the relationship between primary oral cancer and lymph node metastasis in a series of patients with synchronous and metachronous metastases by 2 clonality tests: mt-DNA and TP53 sequence analysis. 25530302

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 AlteredExpression BEFREE The study aims to evaluate the expression and activity of glycogen synthase kinase 3 isoforms α/β (GSK3α/β) and to assess their oncogenic potential through a correlation with the expression of cyclin D1 and p53 in oral cancer. 25645517

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE Randomized, controlled phase II study of post-surgery radiotherapy combined with recombinant adenoviral human p53 gene therapy in treatment of oral cancer. 23722592

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE Evaluation of p53 protein as a prognostic factor for oral cancer surgery. 23791033

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE Mutated TP53 and LOH at 9p in the biopsy, as single markers and in combination, were significant risk factors for malignant progression of leukoplakia to oral cancer (Kaplan-Meier analysis, p<0.05). 24120275

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE A high percentage of TP53 mutations were observed in OC (30%) and OPMD (average 20%) lesions (p=0.000). 23722122

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 GeneticVariation BEFREE Therefore, the present study evaluated the role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India. 23621193

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker BEFREE These results could justify more extensive research to assess p53 and HER-2/neu gene status as significant prognostic factors in oral cancers. 24399009

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 Biomarker CTD_human Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. 24224046

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.600 AlteredExpression BEFREE We earlier observed altered expression of p53 and Bcl-xL in oral cancer cell lines/tissues and wanted to evaluate these proteins for prediction of radiotherapy response and outcome. 22987535

2013