Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0153452
Disease: Malignant neoplasm of gallbladder
Malignant neoplasm of gallbladder 		0.060 Biomarker BEFREE CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer. 30276551

2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0153452
Disease: Malignant neoplasm of gallbladder
Malignant neoplasm of gallbladder 		0.060 Biomarker BEFREE In conclusion, miR-143-3p suppresses tumour angiogenesis and growth of GBC through the ITGA6/PI3K/AKT/PLGF pathways and may be a novel molecular therapeutic target for GBC. 29416013

2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0153452
Disease: Malignant neoplasm of gallbladder
Malignant neoplasm of gallbladder 		0.060 Biomarker BEFREE Taken together, these findings indicate that DSN induces GBC apoptosis through inhibiting ROS-mediated PI3K/AKT signalling. 28656003

2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0153452
Disease: Malignant neoplasm of gallbladder
Malignant neoplasm of gallbladder 		0.060 AlteredExpression BEFREE The depletion of BRD4 in GBC cell lines resulted in obvious cell apoptosis and downregulated the expression levels of Bcl-2, p-PI3K and p-AKT. 28766687

2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0153452
Disease: Malignant neoplasm of gallbladder
Malignant neoplasm of gallbladder 		0.060 GeneticVariation BEFREE Mutations in exons 9 (E542K, E545G, E545K) and 20 (H1047L and H1047R) of PI3K were determined by direct sequencing in 130 cases of GBC. 26947513

2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0153452
Disease: Malignant neoplasm of gallbladder
Malignant neoplasm of gallbladder 		0.060 AlteredExpression BEFREE We found that activation of the PI3K/Akt pathway was involved in the oncogenic functions of SPOCK1 in GBC. 25623055

2015