Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE As high glucose is able to induce the expression of epidermal growth factor (EGF), which is intimately related with tumor progression, the aim of this study was to evaluate whether curcumin could influence the high glucose-induced EGF/EGFR pathway and the biological activity of pancreatic cancer cells. 30542713

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE We show that CRISPR-mediated knockout of ID1 in glioblastoma cells, breast adenocarcinoma cells, and melanoma cells dramatically reduced tumor progression in all three cancer systems through transcriptional downregulation of EGF, which resulted in decreased EGFR phosphorylation. 31292163

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE However, Epidermal Growth Factor (EGF) promotes tumor progression even with significant EGR1 upregulation. 30845713

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Together, our findings indicate a complex mechanism underlying PGE<sub>2</sub>-induced EGF/EGFR signaling and transcriptional control, which plays a key role in cancer progression. 29599917

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This phenomenon may be attributed to the cross talk between TGF-β signaling and other pathways, including EGF receptor (EGFR) signaling during cancer progression. 29215776

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Altogether, our studies reveal a crucial link of EGF receptor to NF-κB activation and tumor progression. 27991920

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Epidermal growth factor receptor (EGFR) and Cortactin are molecular markers that are important in tumour progression and development, and interact within the EGF pathway. 29201160

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Stress-induced EGF receptor signaling through STAT3 and tumor progression in triple-negative breast cancer. 28088463

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These results suggest that HB-EGF secreted from KRas-mutated colorectal cancer cells promotes IMF migration through ERK and JNK activation, which, in turn, could support cancer progression. 28339087

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE TU-100 and some of its components and metabolites of these components inhibit tumor progression in two mouse models of colon cancer by blocking downstream pathways of EGF receptor activation. 27730672

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Therefore, our findings suggest that AQP3 is required for EGF-EGFR cell signaling in cancer cells and is a therapeutic target for cancer progression. 26896765

2016

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Supporting biological relevance, increased levels of EGF receptor during tumor progression were correlated with increased expression of the UPR gene signature. 26551735

2016

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Growth factors of the epidermal growth factor (EGF)/neuregulin family are involved in tumor progression and, accordingly, antibodies that intercept a cognate receptor, epidermal growth factor receptor (EGFR)/ERBB1, or a co-receptor, HER2, have been approved for cancer therapy. 25915843

2016

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Although EGFRvIII is constitutively active and promotes cancer progression, its activity is attenuated compared with EGF-ligated wild-type EGFR, suggesting that EGFRvIII may function together with other signaling receptors in cancer cells to induce an aggressive phenotype. 25347738

2015

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Cripto, the founding member of the EGF-CFC genes, plays an essential role in embryo development and is involved in cancer progression. 25629528

2015

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Synergistic effect of lung tumor-associated dendritic cell-derived HB-EGF and CXCL5 on cancer progression. 24346967

2014

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE However, there are limited data regarding the EGF-mediated signaling affecting functional cell properties and the expression of extracellular matrix macromolecules implicated in cancer progression. 24792576

2014

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The results suggest that proHB-EGF may play an important role in tumor progression. 23349913

2013

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Epidermal growth factor (EGF) plays a critical role in malignant transformation of hepatocytes and tumor progression. 23419149

2013

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Due to the interaction between HER2 and other ErbB receptors, HER2 is implicated in the EGF family of ligands-regulated tumor progression. 23542467

2013

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE EGF receptor (EGFR) and MET (the receptor tyrosine kinase for hepatocyte growth factors) are cell-surface tyrosine kinase receptors that have been implicated in diverse cellular processes and as regulators of several microRNAs (miRNAs), thus contributing to tumor progression. 23650389

2013

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE MET, a receptor tyrosine kinase for hepatocyte growth factor, is associated with tumor progression and acquired resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI). 21733594

2012

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Although HB-EGF is widely expressed in tumors when compared with normal tissue, its contribution to cancer progression remains obscure. 22209887

2012

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These results indicate that EGF may affect claudins and tight junctional functions in ovarian cancer cells during cancer progression. 22544349

2012

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE While elevated expression of HB-EGF in cancer cells and its contribution to tumor progression are well documented, the effects of HB-EGF expression in the tumor stroma have not been clarified. 22009535

2011