Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Moreover, a PTEN inhibitor abolished EHD1 shRNA regulation of EGFR-TKI sensitivity, EMT, and cancer progression. 31740781

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Alterations in the epidermal growth factor receptor (EGFR) and PI3K pathways in head and neck squamous cell carcinomas (HNSCC) are frequent events that promote tumor progression. 31124563

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE We found that EGFR is activated in grade II and grade III chondrosarcoma tumors but not in grade I tumors, suggesting a role in tumor progression. 31139331

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Somatic aberrations of BRCA1 gene are associated with ALDH1, EGFR, and tumor progression in prostate cancer. 30265376

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The epidermal growth factor receptor (EGFR) and RAS/RAF signaling pathway plays pivotal roles in tumor progression via proliferation, survival, invasion, and immune evasion. 30968289

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Since EGFR and c-Met are both implicated in oncogenesis and tumor progression, we initiated a screening program by using an in-house library to identify agents capable of inducing the concomitant suppression of EGFR and c-Met expression, which led to the identification of compound 1, a 1,2,4-oxadiazole derivative. 31446247

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Recent studies in cancer progression have shown that in addition to activating the canonical Smad signaling pathway, TGFβ can also transactivate the epidermal growth factor receptor (EGFR) to enhance invasive cell migration. 30290164

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE The EGFR resistance mutation T790M should be monitored at cancer progression. 31445213

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. 30621788

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE <b>Conclusions:</b> Our findings indicate that IL-22 plays a role in tumor progression and EGFR-TKI resistance in NSCLC. 31750252

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. 31493743

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Our model implies that combining GR modulation to EGFR inhibition may yield an effective treatment strategy in halting cancer progression. 31052457

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In the case of tumor progression under treatment with third-generation <i>TKIs</i> the <i>EGFR C797S</i> mutation in the <i>cis</i> or <i>trans</i> positions is looked for. 30775029

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE GPAA1 facilitates the expression of cancer-related GPI-anchored proteins and supplies a more robust platform-the lipid raft-to promote EGFR-ERBB2 dimerization, which further contributes to tumour growth and metastasis and to cancer progression. 31118109

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The epidermal growth factor receptor (EGFR) pathway substrate 8 (Eps8) gene is involved in regulating cancer progression and is considered an attractive target for specific cancer immunotherapy. 31031152

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Finally, inhibition of EGFR and c-RAF expression effectively blocked tumor progression in nine independent patient-derived xenografts carrying KRAS and TP53 mutations. 30975481

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The EGFR/Eps8 complex is involved in regulating cancer progression and might be an ideal target for antitumor therapy. 31118055

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In conclusion, epidermal LRIG2 excess is associated with activated EGFR/ERBB4-MAPK signaling and accelerated tumor progression in experimentally induced NMSC, suggesting LRIG2 as a potential oncoprotein in skin. 31580518

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The mechanical modulation of EGFR/ERK during growth-mediated competition for space may contribute to tumor progression. 30554899

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE KEY POINTS: A rare exon 18 epidermal growth factor receptor mutation with sensitivity to afatinib is reported.Small cell transformation was observed at tumor progression.Acquisition of a SMAD4 mutation was observed at tumor progression. 30413663

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE A total of 1988 patients receiving first-line gefitinib or erlotinib for the treatment of EGFR-mutated advanced lung adenocarcinoma, with the exclusion of TCM users after tumor progression, were included in this cohort study. 30836771

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Epidermal growth factor receptor signalling blockade increases CCL5 expression that regulates either the anti-tumour immune response or tumour progression. 30554073

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This review mainly focused on modulation of genes like CD44, EGFR, and Rac pathway intermediates which play a crucial role in the tumor progression, metastasis, proliferation, and invasion characteristics in epithelial cancers with EMT properties. 30799784

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE EGFR and EGFRvIII cooperate to promote tumor progression and invasion, in part, through activation of the Stat signaling pathway. 29724813

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Detection of EGFR mutations in circulating cell-free DNA (cfDNA) is beneficial to monitor the therapeutic effect, tumor progression, and drug resistance in real time. 30128808

2018