Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE A great hallmark of breast cancer is the absence or presence of estrogen receptors ERα and ERβ, with a dominant role in cell proliferation, differentiation and cancer progression. 31401293

2020

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In conclusion, our findings demonstrated that ERα, but not ERβ, is involved in leptin-induced ovarian cancer in an E2-independent manner, providing new evidence for cancer progression in obesity-associated ovarian cancer. 31077012

2019

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE In this study, we identified that ER alpha (ERα) expression on the macrophages of human endometrial cancer was positively correlated with cancer progression. 30779215

2019

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The study demonstrates that ERα upregulates LINC00472 which suppresses the phosphorylation of NF-κB, and suggests that endocrine treatment may lower LINC00472 and increase NF-κB activities, leading to tumor progression and disease recurrence. 30830488

2019

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE To investigate the clinical implications of 17β-estradiol (E2) in estrogen receptor α (ERα)-negative female cancer progression as well as the underlying biological mechanisms. 30956772

2019

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Thus, the aim herewith was to evaluate the effects of associating anti-inflammatory and antiangiogenic therapies on cancer progression, correlating them with steroid hormone receptor (AR and ERα), reactive stroma (vimentin, αSMA, and TGF-β), and cell proliferation (PCNA) markers expression in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model. 30585351

2019

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Several groups have used sensitive detection methods using patient liquid biopsies to track ESR1 or truncal somatic mutations to predict treatment outcome and tumor progression, and some of these techniques may eventually be used to guide sequential treatment options in patients. 31318440

2019

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These models suggest that estrogen receptor (ER) signaling promotes expansion of the transformed population and that subsequent accumulation of somatic mutations that drive cancer progression occur via metabolic activation of cathecol estrogens or by epigenetic mechanisms. 28595943

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE To evaluate the role of constitutive epigenetic changes in normal body cells of BRCA1/BRCA2-mutation negative patients, we have developed a deep bisulfite sequencing assay targeting the promoter regions of 8 tumor suppressor (TS) genes (BRCA1, BRCA2, RAD51C, ATM, PTEN, TP53, MLH1, RB1) and the estrogene receptor gene (ESR1), which plays a role in tumor progression. 29659014

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Estrogen receptor alpha (ER alpha) is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. 29433542

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In this work, the role and effects of food-contained polyphenols in hormone-related cancers will be reviewed, mainly focusing on the different polyphenols' mechanisms of action with particular attention on their estrogen receptor-based effects, and on the consequences of such processes on tumor progression and development. 30189583

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Estrogen receptor signaling in prostate cancer: Implications for carcinogenesis and tumor progression. 29094395

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In summary, while <i>PTENP1</i> upregulation decreased <i>PTEN</i> transcript levels and stimulated the growth of ER-positive breast cancers, increased <i>PTEN</i> transcript levels and inhibited tumor progression was observed in the ER-negative cells.<b>Implications:</b> This report highlights the profound biological activity of <i>PTENP1</i> in breast cancer, which is dictated by the hormone receptor status.<i></i>. 29021233

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The loss of estrogen receptor α (ERα) expression in breast cancer constitutes a major hallmark of tumor progression to metastasis and is generally correlated to a strong increase in Hyaluronic Acid (HA) turnover. 29753772

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Estrogen receptor α is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. 29100376

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE ERα therefore functions as a transcriptional effector of cytokine-induced IKKβ signaling, suggesting a mechanism through which the tumor microenvironment controls tumor progression and endocrine resistance. 28306507

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In brief, the expression of estrogen receptor was associated with an improved overall survival (HR = 0.86, 95% CI = 0.76-0.97), whereas there was no significant difference between estrogen receptor and time to tumor progression among epithelial ovarian cancer patients. 28977954

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE On the other hand, it has been recently shown that knockdown of the estrogen receptor α (ERα) in low invasive MCF-7 (ERα+) breast cancer cells and the suppression of ERβ in highly aggressive MDA-MB-231 (ERβ+) cells significantly alter the functional properties of breast cancer cells and the gene expression profile of matrix macromolecules related to cancer progression and cell morphology. 28332606

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The hormone sensitivity of melanoma and the role of 'classical' oestrogen receptor (ER) α and β in tumour progression have been intensively studied with rather contradictory results. 28467693

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We compared stable knockdowns of furin, PACE4 and PC7 in the estrogen-receptor-positive cell line ZR-75-1 to evaluate their respective contribution to cell growth and tumor progression. 28347547

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE This study showed that miR-222 is associated with down-regulation of the estrogen receptor, EMT, and tumor progression in hormone receptor-positive breast cancer, indicating that miR-222 might be associated with endocrine therapy resistance and poor clinical outcome in hormone receptor-positive breast cancer. 28382093

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE A high amount of adipocytes enhances cancer progression due to the increased expression of HIF-1α which causes the loss of ER α protein as stated in four articles. 28993797

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Several factors have been proposed for endocrine therapy failures, which include molecular alterations in the estrogen receptor pathway, altered expression of cell-cycle regulators, autophagy, and epithelial-to-mesenchymal transition as a consequence of tumor progression and selection pressure. 29129161

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In addition to the protective effects against neoplastic progression, estrogen treatment resulted in an epithelium that exhibited features distinctive from a normal prostate, including increased androgen-insensitive basal cells, high androgens and estrogen receptor positivity, and changes in DNA methylation patterns. 28401578

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These findings provide insight into the mechanism of genomic instability in ERα-positive breast cancer and suggest that individuals with mutations in RAD51C that are exposed to estrogen would be more susceptible to accumulation of DNA damage, leading to cancer progression. 27753535

2016