Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Our study was designed to explore the impact of MDM2 overexpression on the levels of various cell cycle regulatory proteins including Aurora kinase-B (AURK-B), CDC25C and CDK1, which are known to promote tumor progression and increase metastatic potential. 31706019

2020

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE More than 50% mutations in human cancers along with the increase in expression of murine double minute 2 gene (mdm2), has been found as one of the reason for cancer progression. 30551517

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Collectively, these data uncover a previously unsuspected function of the MDM2 oncoprotein in mitochondria that play critical roles in skeletal muscle physiology and may contribute to tumor progression. 29452639

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Our findings suggest that MDM2 inhibitors could reduce cancer progression in part by reducing the pro-inflammatory environment created by senescent cells. 29402901

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Mouse double minute 2 (MDM2) and vascular endothelial growth factor (VEGF) are important molecules involved in tumor progression. 28274247

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. 29153842

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The p14ARF/MDM2/ TP53 pathway is known to play an important role in tumor progression by cell cycle control, although the association between this pathway and the prognosis of esophageal squamous cell carcinoma (ESCC) is unclear. 27414035

2016

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE A requirement for Mouse Double Minute 2 (MDM2) oncogene activation has been suggested to be associated with cancer progression and metastasis, including breast cancer. 25271708

2014

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE RMS-YM may be useful for studies of the molecular pathways of tumorigenesis and tumor progression in rhabdomyosarcoma and for in vitro evaluation of newly developed therapeutic agents that target MDM2 or FRS2. 24480864

2014

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The MDM2-p53 feedback loop plays an important role in tumor progression and thus, increased understanding of the pathway has the potential to improve clinical outcomes for cancer patients. 25477334

2014

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Therefore, the binding of Mdm2 to the Slug mRNA appears to provide a novel mechanism through which Mdm2 promotes tumor progression in a manner independent of the presence of p53. 23438693

2013

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The data from the current study provide the first evidence that hdm2 mRNA is frequently mutated by alternative splicing in colorectal cancer, and may play a role in colorectal tumorigenesis or cancer progression. 21761395

2012

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We will illustrate the importance of these interactions with Mdm2 and discuss how this is important for tumor progression, cellular proliferation in cancer. 23208375

2012

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Thus, PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus. 21804542

2011

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Identification of Hdm2 as a downstream target of TGF-beta1 represents a critical prosurvival mechanism in cancer progression and provides another point for therapeutic intervention in late-stage cancer. 19955655

2010

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Inactivation of p53, by mutations and/or overexpression of the mdm2 gene, confers a selective advantage to tumor cells under hypoxic microenvironment during tumor progression. 20703075

2010

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE A gene-dosage effect on time to tumor progression was observed for polymorphisms in the p73, p16, and MDM2 genes. 19020940

2009

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers. 18314481

2008

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Alteration of the MDM2-p73-P14ARF pathway related to tumour progression during urinary bladder carcinogenesis. 15492852

2004

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Previous studies indicate that some tumors express alternatively or aberrantly spliced Mdm2 variants that are unable to bind p53, but whether these actively contribute to carcinogenesis or are a byproduct of cancer progression has been unclear. 14522887

2003

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These results suggest that the distribution of MDM2 reflects its nuclear-cytoplasmic shuttling ability; that interaction between p53 and MDM2 for tumor progression is not enhanced by point mutations at codon 17; and that the expression of MDM2 splice variants is a reason for the lack of its overexpression. 11859876

2002

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Although heparanase activity seems to play an essential role in tumor progression, expression of oncogenes, such as erbB2 and Mdm2 seems to play the dominant role in the development of ovarian cancer. 11351242

2001

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE These results indicate that EGR-1 is commonly suppressed in gliomas independent of p16/INK4a/ARF and Mdm2 and that suppression is less crucial in tumors bearing p53 mutations, and these results implicate an EGR-1 growth regulatory mechanism as a target of inactivation during tumor progression. 11555594

2001

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We investigated a lipoma and a well-differentiated/dedifferentiated liposarcoma (WD/DDL), occurring simultaneously in one patient for the possible role of p53 and mdm2 in the molecular oncogenesis of liposarcoma and tumor progression. 11518050

2001

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In our study, survival estimation revealed a significant correlation of mdm2 gene amplification with shorter survival time, and support the hypothesis, that mdm2 oncogene activation appears to occur late in tumor progression and may be characteristic as negative prognostic marker. 11212898

2000