Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The ability of TGFβ1 to induce EMT in lung tumors may represent a critical process in cancer progression. 31088909

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The differential modulation of important cellular pathways like TGF-β1 and STAT1 can explain the sensitivity of tissues to HPV cancer progression.<b>IMPORTANCE</b> Although the high-risk human papillomavirus 16 infects anogenital and oropharyngeal sites, the cervical epithelium has a unique vulnerability to progression of cancer. 31189705

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Our results indicate that CEACAM1 overexpression in TSCC may induce transformation of neutrophils from antitumor to protumor type via TGF-β1, which may further promote tumor progression. 30565803

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Taken together, our findings suggest that the TGFβ1 and the MMP-9 feedback loop is critical in tumor progression, as it may aid in the development of treatment strategies that are designed to target both TGFβ and MMP-9. 31499614

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE High expression of TGF-β1, hard tumor texture, and conventional subtype were all independent risk factors for tumor progression. 31349076

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Our findings uncover a new co-receptor for TGF-β1 and bring up new questions on whether CDCP1 cooperates with TGF-β1 to promote cancer progression. 31302030

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Our results suggest that HNSCC patients who exhibit persistently elevated sMICA and TGF-β1 levels after CRT are at higher risk of tumor progression or death. 30096190

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Colorectal cancer tissue expression of TGFB1 gene mRNA correlates with tumor progression and metastasis. 30071009

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We are confirming TGF-β1's role in EMT by means of morphomechanical evidence that could represent a turning point in understanding the molecular mechanisms involved in cancer progression. 30012949

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Second, overexpression of CLP/Cotl1 potentiated the growth-suppressive effect of transforming growth factor-β1 (TGFβ1), leading to downregulation of TGFβ-responsive genes vascular growth factor A/B (VEGFA/VEGFB), hypoxia inducing factor 1α (HIF-1α) and trombospondin 1 (TSP1), which mediate various hallmarks of cancer progression including angiogenesis, invasion and metastasis. 28925397

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Similarly, TGFβ1 and TGFβ3, but not TGFβ2, showed higher expression levels in advanced lymph node-positive and metastatic tumors, suggesting different roles for the different isoforms in tumor progression and the metastatic process, while in the least aggressive molecular subtype (luminal A), expression of the three TGFβ isoforms significantly correlated with expression of both TGFβ receptors, such correlation only occurred between TGFβ1 and TGFβ3 and the TGFβ type II receptor (TβRII) in the highly aggressive basal-like subtype. 29320969

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression. 29799477

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE TGF-beta1, WNT, and SHH signaling in tumor progression and in fibrotic diseases. 27814572

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Here, we applied diricore to a cellular model in which epithelial breast cells respond rapidly to TGFβ1, a cytokine essential for cancer progression and metastasis, and uncovered shortage of leucine. 28274951

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE RNF125 promoting effect on GBC tumor progression was identified to relate with the activation of TGF-β1-SMAD3-ID1 signaling pathway. 28611292

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that is reported to regulate cellular motility and invasive capability during tumor progression. 27350089

2016

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This study suggests that TGFβ1 is involved in CCA tumor progression and participates through miR-34a mediated downstream cascades, and is a target to inhibit CCA development and growth. 27364974

2016

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE However, the role of chemokines in TGFβ1-induced tumor progression still remains unclear. 26212008

2016

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE However, the mechanism of URG-4/URGCP regulation by TGF-β1 and its significance in cancer progression remains largely unknown. 26657209

2016

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hepatocyte-specific basigin/CD147-knockout mice decreased the susceptibility to N-nitrosodiethylamine-induced tumorigenesis by suppressing TGF-β1-CD147 signaling and inhibiting dedifferentiation in hepatocytes during tumor progression. 27041581

2016

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE To date, no data have been reported concerning the influence of PTEN/PI3K signaling pathway on EMT in human esophageal squamous cell carcinoma (ESCC) and how TGF-β1 and PTEN/PI3K act through multiple interconnected signaling pathways to trigger events associated with EMT and tumor progression. 25175594

2014

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE TGF-β1 in tumor microenvironments induces immunosuppression in the tumors and sentinel lymph nodes and promotes tumor progression. 24509168

2014

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We have previously identified a novel CD4⁺CD69⁺Foxp3⁻ Treg subset in tumor-bearing mice, which suppresses CD4 T cell response via membrane-bound transforming growth factor beta 1 (mTGF-β1) and then promotes tumor progression. 24668348

2014

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Transforming growth factor-ß1 (TGF-β1) is a multifunctional cytokine that is involved in various pathophysiological processes, including cancer progression and fibrotic disorders. 24098479

2013

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The TGFβ1 and its receptors have an important role in tumor progression, being the pro-apoptotic function modulated by the expression of TGFBR2. 23951322

2013