Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Studies showed that vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have elevated expression in tumors and are involved in tumor progression and metastasis; suggesting their potential for being a therapeutic target. 31786193

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In addition, expression of phospho-ERK (p-ERK), NF-κB p65 (Ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), X-linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. 31714653

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Chondromodulin-1 and vascular endothelial growth factor-A expression in esophageal squamous cell carcinoma: accelerator and brake theory for angiogenesis at the early stage of cancer progression. 31595395

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE An increased level of Nectin-4 along with representative metastatic (CD-44, Sca1, ALDH1, Nanog) and angiogenic (Ang-I, Ang-II, VEGF) markers were noted in metastatic tumors (local and distant) in comparison to primary tumors that were correlated with different grades of tumor progression. 31617074

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Recently, ramucirumab, a drug that targets vascular endothelial growth factor receptor (VEGFR), was clinically approved; therefore, we evaluated VEGFR2 expression and its predictive roles in tumor progression in clear cell renal cell carcinoma (CCRCC). 31477752

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma. 31427543

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We identify a novel function for OVA66 in regulating an autocrine VEGF-VEGFR2 feed-forward signalling loop that promotes tumour progression and angiogenesis. 30833190

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Neuropilins (NRPs) are cell surface glycoproteins, acting as co-receptors for secreted Semaphorins (SEMAs) and for members of the vascular endothelial growth factor (VEGF) family; they have been initially implicated in axon guidance and angiogenesis regulation, and more recently in cancer progression. 31027288

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Insulin-like growth factor 2 mRNA-binding protein 3 (IMP3) and vascular endothelial growth factor-A (VEGF-A) may play important roles in the process of tumor progression and tumor angiogenesis. 31611984

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE To investigate the role of tumor growth velocity in defining tumor progression in metastatic renal cell carcinoma patients treated with the vascular endothelial growth factor tyrosine kinase inhibitor, sorafenib. 30325072

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE A negative correlation was determined between miR-548c-3p and hypoxia-inducible factor (HIF) 1α or vascular endothelial growth factor (VEGF) levels, indicating that miR-548c-3p inhibited tumor progression by suppressing the HIF1α-mediated VEGF signaling pathway. 31378898

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Sporamin down-regulates the expression and secretion of β-catenin and VEGF in the liver, which subsequently inhibits the transcription of downstream genes involved in cancer progression and angiogenesis. 31333311

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF-C) are thought to be involved in tumor progression and metastasis. 30993496

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Targeting the activin receptor-like kinase 1 (ALK1) and VEGF pathways simultaneously by combining the ALK1 ligand trap dalantercept with sorafenib may result in more effective angiogenic blockade and delay tumor progression in patients with advanced HCC.Although the combination was generally well tolerated, there was no additive antitumor activity with the combination of dalantercept plus sorafenib in patients with advanced HCC. 30352941

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE VEGF and its receptors play a major role in physiologic and pathologic angiogenesis, which is marked in tumour progression and metastasis development. 30499413

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Peripheral blood plasma or mononuclear cell isolates collected prior to therapy and at weeks 8 and 16 and at time of tumor progression were analyzed for vascular endothelial growth factor and regulatory T-cell (Treg) measurements. 29666297

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF) and autotaxin (ATX) play important roles in embryonic vasculogenesis and cancer progression. 30456868

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. 28911884

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The low expression of miR‑1 in CRC may be one of the reasons for the abnormally high expression of VEGF; the upregulation of miR‑1 expression may inhibit cancer progression by downregulating VEGF. 29845255

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE cMet signaling pathway is involved in the resistance to anti-VEGF therapy and cMet overexpression is associated with tumor progression and poor prognosis. 29675102

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Tumor oxygenation mediated by M-Abx specifically occurs within the H2O2-overexpressed tumor microenvironment, and significantly downregulates the content of tumor progression-related proteins, such as HIF-1α, P-gp, and VEGF. 30420976

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Photodynamic therapy (PDT), eliminates not only the tumor, but also modulates signaling factors release, e.g. vascular endothelial growth factor (VEGF), which plays a crucial role in cancer progression. 29079348

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE VEGF-A and angiopoetin-2 clearly play a role as mediators of the vasculogenesis contributing to tumor progression. 29397265

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) are increased in majority species of cancers and suppress tumor progression by blocking VEGF/VEGFR2. 30400838

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) play important roles in cancer progression in various cancer cell lines. 29630948

2018