Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Bioinformatics and biological data indicated CXCR4 is a possible candidate target of miR‑494.3p, known to be involved in tumour progression. 30431073

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Therefore, targeting CXCR4 on tumor cells and neutrophils could serve as a double bladed razor to limit cancer progression. 30787324

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The recent appreciation of neutrophils as active participants in tumor progression and metastasis has drawn attention to a number of chemokine-receptor systems that may drive their recruitment to tumors. 30549315

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Although the CXCL12-CXCR4/CXCR7 chemokine axis is demonstrated to play an integral role in tumor progression, the controversy exists and the role of CXCL12-CXCR4/CXCR7 signaling axis in epithelial-mesenchymal transition (EMT) of human ovarian cancer has not been explored. 30259564

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE A comprehensive clinical validation of the targets in different stages of PanNETs demonstrated the implication of both Sema4D and CXCR4 in tumor progression. 31239269

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE CXCR4 is a chemokine receptor crucial in tumor progression, although the angiogenic role of CXCR4 in oral squamous cell carcinoma (OSCC) has not been investigated. 31336612

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The chemokine receptor 4 (CXCR4) plays an important role in tumor progression. 30554431

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Moreover, CXCR4, with its ligand CXCL12, played a critical role in tumor progression induced by TCF12 via activation of the MAPK/ERK and PI3K/AKT signaling pathways. 31534521

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. 29954928

2019

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE CXCR4/CXCL12 may play roles in tumor progression in MLN and is associated with poor prognosis of lymph-node-positive NSCLC patients. 29032612

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE RT-qPCR analysis revealed that A549 cells cultured in semi-solid Matrigel exhibited a marked decrease in the expression levels of genes that are related to tumor progression and invasion (uPA, uPAR, MMP2, MMP7, MMP9 and CXCR4). 29436672

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The CXCL12-CXCR4 pathway has crucial roles in stem cell homing and maintenance, neuronal guidance, cancer progression, inflammation, remote-conditioning, cell migration and development. 30408103

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE However, the discovery of CXCR7 as another receptor for CXCL12 with rather high binding affinity and recent reports about its involvement in endometrial disease and cancer progression has questioned the potential of "selective blockade"' of CXCR4 to treat these ailments. 30106199

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We focused on signaling by chemokine CXCL12, a hallmark molecule secreted by CAFs, and receptor CXCR4, a driver of tumor progression and metastasis in TNBC. 29416611

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. 29776413

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Thus, with previous experimental evidences, the present review discussed the role of FoxOs in association with metastasis related molecules including cannabinoid receptor 1 (CNR1), Cdc25A/Cdk2, Src, serum and glucocorticoid inducible kinases (SGKs), CXCR4, E-cadherin, annexin A8 (ANXA8), Zinc finger E-box-binding homeobox 2 (ZEB2), human epidermal growth factor receptor 2 (HER2) and mRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-622, subsequently analyzed the molecular mechanism of some natural compounds targeting FoxOs and finally suggested future research directions in cancer progression and metastasis. 28774834

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Studies on different tumor types demonstrate that CXCR4 expression increases in tumor tissues and is linked to metastasis and cancer progression. 29455242

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The chemokine receptor 4 (CXCR4) has been an attractive molecular target for tumor imaging, because it is overexpressed in many tumor types and involved in tumor progression and metastasis. 29370457

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE In conclusion, our findings suggest that CXCR4 might contribute to clinical tumour progression and may be a valuable prognostic biomarker in colorectal cancer treatment. 29719205

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE There has evidence showing that C-X-C chemokine receptor type 4 (CXCR-4) and its ligand, stromal cell-derived factor-1 (SDF-1), plays an important role in cancer progression and metastasis. 28739729

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE However, the underlying mechanisms of CXCL12/CXCR4 axis and cancer progression have been poorly explored. 28176874

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Overexpression of CXCR4 induced by estrogen and the activity of CXCL12/CXCR4 pathway could be a new mechanism by which this hormone supports tumor progression and metastasis. 28318328

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Therefore, High expression of C-X-C chemokine receptor type 4/stromal cell-derived factor-1 which is essential in tumor progression can predict poor survival that may provide more advance prognostic clues to colorectal cancer patients. 28621237

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE CXCR4, a stromal-derived-factor-1 specific chemokine receptor, is highly expressed in non-small cell lung cancer (NSCLC) tissues and participates in cancer progression by regulating cell growth, apoptosis or invasion. 27922681

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 PosttranslationalModification BEFREE CXCR4 stimulates tumor progression by different mechanisms and is required for metastatic spread to organs where CXCL12 is expressed, thereby allowing tumor cells to access cellular niches, such as the marrow, which favor tumor cell survival and proliferation. 29022185

2017