Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Dyslipidemia in LPG generally resembles type III hyperlipoproteinemia with elevated serum apolipoprotein E level. 30685233

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE To better inform prevention, future consideration should be given toward managing dyslipidemia in women carrying the APOE ɛ4 allele. 30689578

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE This study aimed to investigate CF dyslipidaemia, its clinical correlates and links to oxidized low-density lipoprotein (oxLDL), adiponectin, and apolipoprotein E (APOE). 30979683

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE Our study aimed to demonstrate the relationships among the statins response and the ApoE gene common polymorphisms and lifestyle risk factors in Chinese arteriosclerotic cardiovascular disease (ASCVD) patients with dyslipidemia. 31153375

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE APOB, APOC3, and APOE and apolipoprotein-defined lipoprotein subclasses (ADLSs; based on qualitative apolipoprotein complement) have been associated with dyslipidemia and CVD. 31203233

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE APOE genotype associates with food consumption and body composition to predict dyslipidaemia in Brazilian adults with normal-weight obesity syndrome. 28720344

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE The specific aims of current study included to clarify lipidomic perturbation in liver tissues of apolipoprotein E deficient (apoE<sup>-/-</sup>) mice fed with high-fat diet, and to examine the effects of rhodioloside against atherosclerosis and dyslipidemia. 30389273

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE<sup>-/-</sup>) mice fed a high-fat diet to reveal atherosclerosis-induced dyslipidemia. 28527370

2017

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE We have previously shown that MGL affects plaque stability in apolipoprotein E (ApoE)-/- mice, an established animal model for dyslipidemia and atherosclerosis. 28380440

2017

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE We evaluated predictors including demographics, APOE, intellectual enrichment, midlife risk factors (physical inactivity, obesity, smoking, diabetes, hypertension, and dyslipidemia), and the total number of late-life cardiac and metabolic conditions. 28418521

2017

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy. 28777810

2017

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE Overall, 102 patients (53.1%) carried APOE4+ haplotypes and 90 (46.9%) carried APOE4- haplotypes; 189 patients (98.4%) used either a cholinesterase inhibitor, or Memantine, or both; 144 patients had dyslipidemias and 143 of them received statin therapy. 28274859

2017

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE Dyslipidemia and apolipoprotein E4 (APOE ϵ4) allele are risk factors for age-related cognitive decline, but how these risks are modified by human immunodeficiency virus (HIV) infection is unclear. 27448678

2016

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE While both quantitative and qualitative changes of apoE are established causes of rare dyslipidemia syndromes, it remains unclear whether plasma levels of apoE are associated with risk of IHD in the general population. 26761769

2016

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE The study aimed to assess whether the common APOE polymorphism is associated with lipid profiles and dyslipidemia, and it could be modulated by obesity-related traits (body mass index, waist circumference, hip circumference, and waist-to-hip ratio) in Vietnamese children. 27724906

2016

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 AlteredExpression BEFREE We explore the effects of sex; educational level; socioeconomic status; residence area; occupation type; marital status; history of hypertension, diabetes mellitus, and dyslipidemia; tobacco and alcohol use; and APOE ε4 on the rates of cognitive decline. 26902171

2016

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE Polymorphisms of the ApoE (Apolipoprotein E) gene and their influence on dyslipidemia in HIV-1-infected individuals. 25420659

2015

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE The role of apolipoprotein E polymorphism in improving dyslipidemia in obese adolescents following physical exercise and National Cholesterol Education Program Step II intervention. 25870958

2015

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study. 26131702

2015

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE After taking into account confounding factors and correcting for multiple comparisons only APOE rs429358 and rs7412 variants remained significantly associated with risk of dyslipidemia. 26043189

2015

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE Associations of apolipoprotein E and low-density lipoprotein receptor-related protein 5 polymorphisms with dyslipidemia and generalized aggressive periodontitis in a Chinese population. 25329009

2015

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker BEFREE Only APOE*4 conferred a risk against longevity and was associated with high-cholesterol (hTC) and mixed dyslipidemia for oldest-old females. 24746514

2014

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE The APOE p.Leu167del mutation was also found in the proband's son and granddaughter, neither of whom has splenomegaly or marked dyslipidemia. 24314356

2014

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 Biomarker CTD_human Adiponectin expression and the cardioprotective role of the vitamin D receptor activator paricalcitol and the angiotensin converting enzyme inhibitor enalapril in ApoE-deficient mice. 25037058

2014

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias
0.400 GeneticVariation BEFREE We confirm that human schistosomiasis causes dyslipidemia and report for the first time that certain changes in plasma lipid and lipoprotein levels depend on APOE gene polymorphism. 25051269

2014