Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions between SNPs in <i>RGL1:RAD51B</i> (OR=0.44, <i>p</i> value=3.27x10<sup>-11</sup> in overall lung cancer and OR=0.41, <i>p</i> value=9.71x10<sup>-11</sup> in non-small cell lung cancer), <i>SYNE1:RNF43</i> (OR=0.73, <i>p</i> value=1.01x10<sup>-12</sup> in adenocarcinoma) and <i>FHIT:TSPAN8</i> (OR=1.82, <i>p</i> value=7.62x10<sup>-11</sup> in squamous cell carcinoma) in our analysis. 30956756

2019

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE Inactivation of the fragile histidine triad (Fhit) gene has been reported in the majority of human cancers, particularly in lung cancer. 28404875

2017

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE The purpose of the study was to explore the application of artificial neural network model in the auxiliary diagnosis of lung cancer and compare the effects of back-propagation (BP) neural network with Fisher discrimination model for lung cancer screening by the combined detections of four biomarkers of p16, RASSF1A and FHIT gene promoter methylation levels and the relative telomere length. 27766520

2017

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction. 28714963

2017

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE Thus the diagnostic role of FHIT gene in the lung cancer may be relatively limited in the Caucasian population but useful in the Asians. 28036263

2017

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 PosttranslationalModification BEFREE The SVM and DT models for diagnosing lung cancer were successfully developed through the combined detection of p16, RASSF1A and FHIT promoter methylation and RTL, which provided useful tools for screening lung cancer. 27716889

2017

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE These results suggest that the high methylation statuses of p16, RASSF1A, or FHIT genes were associated with a significantly increased risk of lung cancer; the risk of lung cancer increased as the methylation status increased. 23614702

2013

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 AlteredExpression BEFREE Expression of these genes was evaluated by real-time polymerase chain reaction in 55 primary lung cancer samples characterized for FHIT and p53 expression by immunehistochemistry. 22425911

2012

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE These findings suggest FHIT methylation is associated with a higher susceptibility and has a prognostic significance in early stage lung cancer in the Han population of southern-central China and may represent a marker for progressive disease. 20814237

2010

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE The aim of this study was to identify FHIT gene alterations in bronchoscopy specimens of patients with suspected lung cancer and to determine the molecular relevance, if any, of FHIT alterations in the development of cancer. 19267103

2009

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE Detecting FHIT deletions for lung cancer diagnosis produced 58% sensitivity in the enriched sputum, whereas there was 42% sensitivity in the unenriched samples (P = .02). 18484646

2008

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population. 17609851

2007

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE FHIT, WWOX and other tumor suppressor genes are frequently epigenetically inactivated in lung cancers. 17019711

2007

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE Furthermore, abnormal cells were found in 76% sputum by detecting combined HYAL2 and FHIT deletions whereas in 47% sputum by cytology, of the cancer cases, implying that detecting the combination of HYAL2 and FHIT deletions had higher sensitivity than that of sputum cytology for lung cancer diagnosis. 17255269

2007

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan. 15935551

2006

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE FHIT protein enhances paclitaxel-induced apoptosis in lung cancer cells. 16231322

2006

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE The fragile histidine triad (FHIT) gene located at the 3p14.2 locus plays an important role in the pathogenesis of lung cancer. 16513840

2006

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 AlteredExpression BEFREE Using the LightCycler RT-PCR assay, decreased FHIT gene expression might occur early and play an important role in lung tumorigenesis and also correlate with the prognosis of lung cancer. 16800968

2006

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered in 80% of tobacco-associated lung cancers. 16115913

2005

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE These results indicate that M-TB infection is associated with FHIT gene LOH in lung cancer. 15723714

2005

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE LOH of the FHIT locus was frequently found among the lesions of hyperplasia and atypical hyperplasia obtained from 6 patients with a 1- to 36-year history of PT (12 of 30 informative lesions, 40%); none of 70 hyperplastic lesions obtained from 14 patients with a 1- to 11-month history of PT showed LOH at the FHIT gene; 17 of 20 (85%) cancer lesions obtained from 20 lung cancer patients with a 2- to 53-year history of previous PT showed LOH at the FHIT gene, which was significantly higher than hyperplasia and atypical hyperplasia obtained from patients with a 1- to 36-year history of PT in FHIT LOH (Fisher's exact test p = 0.003). 15627891

2005

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker BEFREE The fragile histidine triad protein (FHIT) is a putative tumor suppressor in patients with lung cancer. 15671544

2005

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 Biomarker CTD_human The FHIT gene plays important roles in cancer development, including lung cancers, in which the Fhit protein is frequently lost. 16061637

2005

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE Aberrations of the tumor suppressor genes FHIT and p53 are frequently associated with a wide range of human cancers, including lung cancer. 15313915

2004

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation BEFREE The fragile histidine triad (FHIT) gene, located at chromosome 3p14.2, is deleted in many solid tumors, including lung cancer. 14976524

2004