Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE Linc-ROR regulates apoptosis in esophageal squamous cell carcinoma via modulation of p53 ubiquitination by targeting miR-204-5p/MDM2. 31541467

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE A total of 399 resected cases of ESCC were examined by dual-color in situ hybridization for MDM2 and immunohistochemistry for p53 using tissue microarrays. 31004651

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE A combination assay using SCC-antigen together with s-p53-Abs and s-MK clearly increased our capability to detect esophageal squamous cell carcinoma. 30778774

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE In sum, this study revealed that miR-488-3p inhibited proliferation and induced apoptosis by targeting ZBTB2 and activating p53 pathway in esophageal squamous cell carcinoma, providing a novel biological target for ESCC. 31243806

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC. 31071450

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 GeneticVariation BEFREE TP53 mutations in tumor tissue were identified in 3 of 5 patients with ESCC. 31846968

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE <i>LincRNA-p21</i> leads to G1 arrest by p53 pathway in esophageal squamous cell carcinoma. 31308755

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE Phospholipase C epsilon-1 (PLCE1), IKKα, IKBα, p65, and p53 were highly expressed in ESCC tissues. 30537494

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE Mechanistically, PGM5-AS1 was transcriptionally activated by p53 and it could directly interact with and sequester miR-466 to elevate PTEN expression, thereby inhibiting ESCC progression. 31185143

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 GeneticVariation BEFREE Similarly, p53 methylation with genotype TT was associated with increased EPL and ESCC risks (OR = 13.28, 95% CI 1.67-105.70; OR = 15.24, 95% CI 1.90-122.62). 31754346

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE Overexpression of TRAF4 in ESCC was also associated with high expression of ki-67 and p53 (P<0.05). 30933965

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE The long non-coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma. 29568233

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE However, little information is available about the prognostic significance of perioperative serum p53 antibody (s-p53-Abs) titers in patients with esophageal squamous cell carcinoma. 29959634

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 GeneticVariation BEFREE We focused on two high-frequent mutations TP53 p.G245C and TP53 p.R273H and investigated their oncogenic roles in ESCC cell lines, p53-defective cell lines H1299 and HCT116 p53-/-. 30126368

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE Clinical Value of Serum p53 Antibody in the Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma. 29491120

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE Predictive value of p53 for survival is debatable, hence this study was formulated to know the survival of patients with p53 expression in ESCC. 28937022

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE Therefore, <i>SOX2</i> might be considered as a potential prognostic indicator and a potential target for therapeutic targets in ESCC. p53 staining and combined p53 and Cyclin D1 expression had significantly unfavorable prognostic value for patients with ESCC. 30210237

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE In addition, treatment of ESCC cells with bufotalin markedly activated tumor protein p53 (p53) phosphorylation. 29434851

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 GeneticVariation BEFREE PRIMA-1 exhibits a significant antitumor effect, inducing massive apoptosis through the upregulation of Noxa in ESCC with TP53 missense mutations. 29168598

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins. 30333480

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 GeneticVariation BEFREE TENM3 mutations and the TP53 hotspot mutation p.R213* are independent prognosticators for poor survival in ESCC. 29351612

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 GeneticVariation BEFREE Moreover, the detection of pathogenic variants, including single nucleotide substitution of TP53 (c.346C>T) and BRCA2 (c.6952C>T) and splicing of KDM6A (c.1194+2T>G), suggest that the development of ESCC in the patient was triggered by impairment of checkpoint and repair for DNA damage and epigenetic modification through accumulation of gene mutations induced by chronic graft-versus-host disease and prolonged administration of tacrolimus. 30499911

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 Biomarker BEFREE The Presence of Serum p53 Antibody Predicts the Pathological Tumor Response to Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and Fluorouracil (DCF) in Esophageal Squamous Cell Carcinoma. 27637603

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE Survival analysis revealed that high ASPP2 expression was significantly associated with increased 5-year OS (P = 0.001) and DFS rates (P = 0.010) and that high P53 expression was significantly associated with a reduced 5-year DFS rate of ESCC patients (P = 0.015). 28103919

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
Squamous cell carcinoma of esophagus
0.600 AlteredExpression BEFREE HPV infection and p53 and p16 expression are not prognostic factors in ESCC. 29046713

2017