Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.040 AlteredExpression BEFREE Compound 3c exhibited promising antiproliferative activity in HCT-116 interrogating that hydrogen bond-acceptor mediates ligand/PI3Kα complex formation on m- position. 30207238

2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.040 AlteredExpression BEFREE Biological screening revealed that the newly synthesized compounds inhibit PI3Kα activity in human colon adenocarcinoma (HCT-116), breast adenocarcinoma (MCF-7), and breast carcinoma (T47D) cell lines. 29651943

2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.040 AlteredExpression BEFREE In this study, the inhibitory effect of KYNA on activation of phosphoinositide 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase (MAPK) signaling pathways in colon adenocarcinoma HT-29 cells was revealed. 25012123

2014
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.040 Biomarker BEFREE In parallel, KRASG12V enhances the ability of colon adenocarcinoma cells Caco-2 to migrate and invade through filopodia formation and PI3K-dependent Cdc42 activation. 21943101

2011