Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Here, we report ARHGAP4 as a new regulator of the β-catenin pathway that regulates cell invasion and migration of pancreatic cancer as well as the downstream effector MMP2 and MMP9 expression in vitro. 30958531

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE By combination of results from expression, survival and correlation analysis demonstrated that MMP9/ITGB1-miR-29b-3p-HCP5 competing endogenous RNA (ceRNA) sub-network was linked to prognosis of pancreatic cancer. 31061236

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer. 30941918

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE The expression of MMP-2 and MMP-9 is associated with angiogenesis in pancreatic cancer. 26866436

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE CCL21 regulates pancreatic cancer immunity possibly through governing the expression of a panel of tumor-associated genes, including MMP-9. 29687228

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Knockdown of TM4SF1 inhibited the migration and invasion of pancreatic cancer cells by regulating the expression and activity of MMP-2 and MMP-9, which suggests that TM4SF1 may play a significant role in metastasis in pancreatic cancer. 27459514

2016

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion. 25883224

2015

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker CTD_human Exocrine pancreatic carcinogenesis and autotaxin expression. 22952646

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer. 22159401

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Slug, E-cadherin, and MMP-9 expression in pancreatic cancer was significantly associated with lymph node metastases and we found a significant correlation between Slug and MMP-9 expression; however, no significant correlation was observed between Slug and E-cadherin expression. 21283078

2011

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Resveratrol inhibited the proliferation of 4 different human PaCa cell lines, synergized the apoptotic effects of gemcitabine, inhibited the constitutive activation of NF-kappaB and expression of bcl-2, bcl-xL, COX-2, cyclin D1 MMP-9 and VEGF. 19908231

2010

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE The combination of VNN1 and MMP9 showed the best discrimination of pancreatic cancer-associated diabetes from type 2 diabetes. 20571492

2010

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Down-regulation of DR3 in PaC cells was found to down regulate activated pNF-kappaB/p65, pIkBalpha/beta kinases (pIKK's), MMP9 and XIAP that mostly impart chemoresistance in PaC. 19670328

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. 18410405

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE TRAIL can stimulate the expression of uPA, IL-8, MMP-7 and MMP-9 in pancreatic cancer cell lines, especially in Colo357wt. 18397859

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Our findings indicated that NF-kappaB-mediated MMP-9 and uPA induction was responsible for EGF-induced invasiveness in these pancreatic cancer cell lines and implicate that such anti-NF-kappaB therapy as the use of NF-kappaB inhibitors may contribute to the reduction of invasiveness of pancreatic cancer. 16340751

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. 16510599

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Tumor-associated trypsinogen (TAT), urokinase-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2), and MMP-9 each play a dominant role in the degradation of extracellular matrix (ECM) during the invasion process of pancreatic cancer. 15257104

2004

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE These findings suggest that GDNF modulates MMP-9 expression and activation, and this may promote pancreatic cancer invasion. 12947332

2003

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. 12167581

2002

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Steady-state levels of transcripts encoding extracellular matrix proteins, MMP-2 (72-kDa collagenase IV), MMP-9 (92-kDa collagenase type IV), TIMP-1 and TIMP-2 were elevated in the majority of pancreatic-cancer tissue samples as compared to control pancreatic tissue. 7635566

1995