Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE KLF6 IVS 1-27 G > A may not be associated with cancer susceptibility, especially the susceptibility of unselected prostate cancer. 29970714

2018

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. 23219426

2013

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE Klf6 protein levels significantly decreased with progression in the TRAMP model of prostate cancer (P < 0.05), but there was no difference in Klf6 promoter methylation. 22782870

2013

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE This study investigated the prevalence and significance of KLF6 exon 2 mutations and splice variants (SVs) in different stages of human PC progression. 22819534

2012

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE In addition, a common germline polymorphism in the KLF6 gene associated with increased prostate cancer risk in a large multi-institutional study of 3411 men results in increased expression of KLF6-SV1. 19097929

2009

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. 18596922

2008

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Our study strongly supports the notion that KLF6 and TP53 mutations are not frequent events in prostate cancer. 19020536

2008

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE This study proposes that variation at putative 8q24 cis-regulator(s) of transcription can significantly alter germline c-MYC expression levels and, thus, contribute to prostate cancer susceptibility by down-regulating the prostate tumor suppressor KLF6 gene. 18190704

2008

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Kidney and prostate cancers are leading causes of death in the world, and accumulating evidence suggests that tumor suppressor gene, Krüppel-like factor 6 (KLF6), plays an important role in both the development and the progression of cancer. 18719336

2008

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE The rs3750861 affects expression of KLF6 splicing variants in prostate cancer and we found that its rare allele is associated with reduced lung cancer risk (odds ratio, 0.5; 95% CI, 0.3-0.8). 17223258

2007

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Our results do not support the suggested association of KLF6 IVS1 -27G>A germline polymorphism with pCA risk and also suggest that the variant is not a risk allele for BPH in the Finnish population. 17125911

2007

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE PAC1-R null isoform expression in human prostate cancer tissue. 16372333

2006

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE The negative association between KLF6 IVS1-27A and prostate cancer risk supports a population-specific effect of susceptibility alleles in prostate tumorigenesis. 16598737

2006

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE These observations provide additional evidence for a role of PACAP and PAC1 R in the events determining the outcome of PCa. 16888207

2006

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ERK), KLF6, mitochondria DNA, p53, PTEN, and RAS that have somatic mutations in sporadic prostate cancer; AR, BRCA1, BRCA2, CHEK2 (RAD53), CYP17, CYP1B1, CYP3A4, GSTM1, GSTP1, GSTT1, PON1, SRD5A2, and VDR that have germline genetic variants associated with either hereditary and/or sporadic prostate cancer; and ANXA7 (ANX7), KLF5, NKX3-1 (NKX3.1), CDKN1B (p27), and MYC that have genomic copy number changes affecting gene function. 16267836

2006

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Here we show that a germline KLF6 single nucleotide polymorphism, confirmed in a tri-institutional study of 3,411 men, is significantly associated with an increased relative risk of prostate cancer in men, regardless of family history of disease. 15735005

2005

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Recently, high frequency (42%) of KLF6 mutations have been reported in colorectal cancers (CRC) as in prostate cancers, astrocytic gliomas and hepatocellular carcinomas. 16044160

2005

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Most recently, we identified a common KLF6 germ line single nucleotide polymorphism that is associated with an increased relative risk of prostate cancer and the increased production of three alternatively spliced, dominant-negative KLF6 isoforms. 15994951

2005

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE These data indicate that acetylation may regulate KLF6 function, and its loss in some tumor-derived mutants could contribute to its failure to suppress growth in prostate cancer. 16230382

2005

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Our data suggest that KLF6 germ-line mutations are of marginal importance in prostate cancer predisposition in Finland. 15247715

2004

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. 15064720

2004

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE Krüppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcriptional factor, which has been suggested to be a candidate tumor suppressor gene in prostate cancer and astrocytic glioma. 15172991

2004

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Kruppel-like factor 6 (KLF6) is a ubiquitous zinc finger tumor suppressor that is often mutated in prostate cancer. 15057748

2004

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE These findings indicate that significant genetic alterations of KLF6 occur in a minority of high-grade prostate cancers. 12651626

2003

Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate cancer. 12740910

2003