Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker BEFREE Here, we provide an overview of the transcription factors that are important in normal prostate homeostasis (NKX3-1, p63, androgen receptor [AR]), primary prostate cancer (ETS family members, c-MYC), castration-resistant prostate cancer (AR, FOXA1), and AR-independent castration-resistant neuroendocrine prostate cancer (RB1, p53, N-MYC). 29530947

2018

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 AlteredExpression BEFREE The decrease of FOXA1 and NKX3-1, and aberrant activation of AR, thus accounts for the decrease of DRAIC during prostate cancer progression to the CR state. 25700553

2015

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker BEFREE NKX3-1 saRNA was transfected into human prostate cancer cells including LNCaP, CWR22R, PC-3, CWR22RV1, DuPro, LAPC4, and DU145. 23836514

2013

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker CTD_human Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. 22610119

2012

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker BEFREE Collectively, our work highlights a novel hierarchical transcriptional regulatory network between NKX3-1, AR, and the RAB GTPase signaling pathway that is critical for the genetic-molecular-phenotypic paradigm in androgen-dependent prostate cancer. 22083957

2012

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker BEFREE NKX3-1 is known as a tumor suppressor gene in prostate cancer but has never been reported in OSCC. 22344708

2012

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker CTD_human Integrative molecular concept modeling of prostate cancer progression. 17173048

2007

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker CTD_human Transcriptional regulation of the homeobox gene NKX3.1 by all-trans retinoic acid in prostate cancer cells. 16817226

2006

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker CTD_human p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line. 17202838

2006

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker MGD Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. 10906459

2000

Entrez Id: 4824
Gene Symbol: NKX3-1
NKX3-1
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.550 Biomarker MGD Roles for Nkx3.1 in prostate development and cancer. 10215624

1999