Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 AlteredExpression BEFREE Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells. 28164237

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Germline mutations in the PTEN gene, which cause Cowden syndrome, are known to be one of the genetic factors for primary thyroid and breast cancers; however, PTEN mutations are found in only a small subset of research participants with non-syndrome breast and thyroid cancers. 26699384

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Once a germline PTEN mutation is found, and a diagnosis of phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome made, the clinical outlook broadens to include higher lifetime risks for multiple cancers, beginning in childhood with thyroid cancer. 25916396

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE Mechanistically, we find that INPP4B, but not PTEN, is enriched in the early endosomes of thyroid cancer cells, where it selectively inhibits AKT2 activation and in turn tumor proliferation and anchorage-independent growth. 25883022

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE Interestingly, KLLN-associated risk of thyroid cancer appears to be gender and PTEN status dependent. 25669429

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE At the present time, no study has been undertaken to consider thyroid cancer treatment via FOXOs and PTEN targeting. 26597586

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. 25694510

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 AlteredExpression BEFREE PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells. 25125078

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 AlteredExpression BEFREE We show that SRC inhibition could rescue SDHD dysfunction-induced cellular phenotype and tumorigenesis only when wild-type PTEN is expressed, in thyroid cancer lines. 25149476

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE Mutations in BRAF, NRAS, KRAS and PTEN, that are known to be involved in thyroid cancer biology, were detected in seven FNA samples. 24834793

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE This was in contrast to patients with PTEN(mut+) who had thyroid cancer (0/39). 24712574

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE A total of 32 of 225 PTEN mutation+ patients (14%) had thyroid cancer: 52% papillary, 28% follicular-variant papillary, 14% follicular, and 6% anaplastic. 23158187

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes. 23066114

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE PTEN hamartoma tumour syndrome (PHTS) encompasses several clinical syndromes with germline mutations in the PTEN tumour suppressor gene, including Cowden syndrome which is characterised by an increased risk of breast and thyroid cancers. 23335809

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Children presenting with thyroid cancer should be tested for PTEN mutations. 21956414

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Germline phosphatase and tensin homolog (PTEN) mutations cause Cowden syndrome (CS), associated with breast and thyroid cancers. 20600018

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 AlteredExpression BEFREE DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells. 19173293

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE We show here that adenosine triphosphate (ATP) regulates PTEN subcellular localization in a variety of different cancer cell lines, including those derived from breast, colon and thyroid carcinomas. 18579579

2008

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Germline PTEN mutations cause 85% of Cowden syndrome (CS), characterized by a high risk of breast and thyroid cancers, and 65% of Bannayan-Riley-Ruvalcaba syndrome (BRRS), characterized by lipomatosis, hemangiomas and speckled penis. 17405772

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 PosttranslationalModification BEFREE PTEN promoter methylation in sporadic thyroid carcinomas. 16487009

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 AlteredExpression BEFREE The phosphatidylinositol 3'-kinase (PI3K) pathway is frequently activated in thyroid carcinomas through the constitutive activation of stimulatory molecules (e.g., Ras) and/or the loss of expression and/or function of the inhibitory PTEN protein that results in Akt activation. 16288007

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE PTEN, a dual-phosphatase tumor suppressor, is inactivated in Cowden syndrome (CS), characterized by high risk of breast and thyroid cancer, and in variety of sporadic cancers. 16436456

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 Biomarker BEFREE Overall, our results suggest that PTEN can function as an important modulator of extracellular matrix proteins in thyroid cancer. 15707585

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 AlteredExpression BEFREE 1alpha,25-Dihydroxyvitamin D3 targets PTEN-dependent fibronectin expression to restore thyroid cancer cell adhesiveness. 15890670

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.600 GeneticVariation BEFREE Moreover, germline mutation of PTEN leads to the development of the related hereditary cancer predisposition syndromes, Cowden disease, and Bannayan-Zonana syndrome, wherein breast and thyroid cancer incidence is elevated. 15254063

2004