Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In this review, we present mouse intestinal cancer models that include alterations in the Wnt, Hippo, p53, epidermal growth factor (EGF), and transforming growth factor β (TGFβ) pathways; models of impaired DNA mismatch repair and chemically induced tumorigenesis are included. 31614493

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Connecting signaling and metabolic pathways in EGF receptor-mediated oncogenesis of glioblastoma. 31386654

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Epidermal growth factor (EGF) and its receptor (EGFR) play an important role in lung carcinogenesis. 30783937

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE ErbB4/KITENIN signaling plays a role in epidermal growth factor receptor (EGFR)-independent EGF pathways mediating the invasiveness and tumorigenesis of colorectal cancer cells. 30360226

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Furthermore, an ectopic expression of the active Mt-YAP5SA, but not inactive Mt-YAP6SA, promotes EGF-independent proliferation and tumorigenesis in BRCA1<sup>-/-</sup> mammary epithelial cells. 30918126

2019

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Our study sheds light on how stress and EGF induce Akt activation and new mechanisms for AMPK-mediated oncogenesis and drug resistance. 30413706

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Epidermal growth factor-like domain multiple 7 (EGFL7) is an important sport stimulating factor and motility related factors significantly enhanced the tumor cell metastasis and overexpressed in many cancers, including hepatocellular carcinoma (HCC), associated with tumorigenesis. 30129142

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE EGF may therefore have a role in the initiation or promotion of oral carcinogenesis. 29843953

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE As a Ras modulator, Nogo-B receptor (NgBR) is required for tumorigenesis through the signaling crosstalk with epidermal growth factor (EGF) receptor (EGFR)-mediated pathways. 30208932

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Alteration of epidermal growth factor (EGF) expression has been recognized as an essential molecular event in pancreatic carcinogenesis. 30464258

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes. 29884818

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE The present study examined the effects of long‑term exposure to EGF and 17β‑estradiol on the proliferation, transformation, expression of markers of stemness, and tumorigenesis of MCF7 human breast adenocarcinoma cells. 29956719

2018

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE However, we demonstrated here that Clk/Clk mice resisted chemical carcinogen-induced tumorigenesis by suppressing epidermal growth factor (EGF) receptor-mediated proliferation signals. 28855649

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Epidermal growth factor (EGF) plays a significant role in tumorigenesis and invasiveness of some cancers. 28185929

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In this study, the effects of HIP1 on the degradation of EGFR, which have important roles in carcinogenesis after EGF stimulation, were examined. 29039605

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The present findings demonstrated that EGF may be involved in the epithelial-mesenchymal transition process via altering the E-cadherin/β-catenin complex and increasing MMP-2 secretion, which may then favor the dissolution of the basement membrane to the benefit of malignant cell clusters, contributing to the development of an invasive phenotype in this <i>in vitro</i> model of tumorigenesis. 28927057

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE CFC1 inhibited Activin A-induced NB cell differentiation and Smad2 phosphorylation in NB cell lines, indicating its involvement in tumorigenesis related to EGF-CFC co-receptor family molecule pathways. 28620148

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE NgBR knockdown in human breast cancer cells reduces Ras membrane localization, inhibits epidermal growth factor (EGF)-stimulated Ras signaling and diminishes tumorigenesis of xenografts in nude mice. 28068323

2017

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE ARL4C overexpression, due to Wnt/β-catenin and EGF/Ras signaling alterations, was involved in tumorigenesis. 27835592

2016

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Aberrant regulation of the EGF receptor family (EGFR, HER2, HER3, HER4) contributes to tumorigenesis and metastasis in epithelial cancers. 26420857

2016

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This study focuses on the second stage, in particular, the role of EGF receptor (EGFR) signaling in angiogenesis and tumorigenesis of Cr(VI)-transformed cells. 27226640

2016

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Taken together, these results support a model whereby Nox1 activity and ROS generation are regulated by Grb2/Cbl-mediated proteolysis of NoxO1 in response to EGF, providing new insight into the processes by which excessive ROS production may promote oncogenic signaling to drive colorectal tumorigenesis. 26781991

2016

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE EGF and EGFR control important processes in carcinogenesis and several differences in this signaling pathway are very common in certain types of cancers. 25964549

2015

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE EGF receptor (EGFR) overexpression is thought to drive head and neck carcinogenesis however clinical responses to EGFR-targeting agents have been modest and alternate targets are actively sought to improve results. 25779657

2015

Entrez Id: 1950
Gene Symbol: EGF
EGF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These studies focus on the EGF family member epiregulin (EREG) as a mediator of early stage breast tumorigenesis. 26215578

2015