Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4301
Gene Symbol: AFDN
AFDN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.030 AlteredExpression BEFREE In conclusion, Afadin is downregulated by <i>H. pylori</i> infection <i>in vitro</i> and <i>in vivo</i>, and its downregulation leads to the emergence of EMT and to the acquisition of an aggressive phenotype in gastric cells, which can contribute to gastric carcinogenesis. 30473688

2018

Entrez Id: 4301
Gene Symbol: AFDN
AFDN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.030 GeneticVariation BEFREE We provide evidence that oligomerization is the dominant mechanism driving oncogenesis from rare MLL translocation partners and employ our mechanistic understanding of MLL-AF6 to examine how dimers induce leukemia. 29062045

2017

Entrez Id: 4301
Gene Symbol: AFDN
AFDN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.030 Biomarker BEFREE Although the AF6 RA1 domain has previously been defined as an interaction surface for guanosine triphosphate-bound Ras, single amino acid substitutions known to abolish the AF6-Ras interaction did not abrogate MLL-AF6-mediated oncogenesis. 20395419

2010