Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MYC proto-oncogene family including c-myc and n-myc (MYCN) are critical for normal cell development and tumorigenesis. 29022893

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. 29523784

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE v-myc avian myelocytomatosis viral oncogene homolog (c-Myc) is an important member protein of the Myc family that is important in cell cycle progression, apoptosis and tumorigenesis. 28765944

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MYC genes have both essential roles during normal development and exert oncogenic functions during tumorigenesis. 27748763

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Mechanistically, nutritional deficiencies could reduce hypoxia-inducible factor α (HIF-1α) protein expression to increase C-MYC protein level, which in turn increased nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM) transcription to enhance the activity of OXPHOS, suggesting that metabolic reprogramming by the changes of microenvironment during the carcinogenesis can provide some novel therapeutic clues to traditional cancer treatments. 26646563

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Thus, MYC appears to initiate and maintain tumorigenesis, in part, through the modulation of immune regulatory molecules. 26966191

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. 25632068

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE This review will focus on mechanisms that contribute to deregulation of MYC expression in pancreatic carcinogenesis and progression and will summarize novel biological findings from recent in vivo models. 26119937

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE Additionally, it was found that the hypomethylation of cis-regulatory sites in the MYC promoter region and the hypermethylation of cis-regulatory sites in the MAX promoter region result in the up-regulation of MYC mRNA expression and the down-regulation of MAX mRNA, which increased the hepatocyte carcinogenesis tendency. 26046465

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis. 26729287

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MYC and p53 have been implicated in gallbladder carcinogenesis. 25200035

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE MYC proteins are overexpressed or deregulated in a majority of malignancies and drive tumorigenesis by inducing widespread transcriptional reprogramming that promotes cell proliferation, metabolism, and genomic instability. 26383167

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that inhibiting MYC may have significant therapeutic value. 25934076

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We and others have shown that MYC alters metabolism during tumorigenesis. 26950360

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MYC is a hallmark molecular feature of both the initiation and maintenance of tumorigenesis. 24890832

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. 25663692

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE However, there have been no studies on the causative role of MYC or any other oncogene in the initiation or maintenance of kidney tumorigenesis. 25964345

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. 25818646

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Our PDAC model supports critical roles of KRAS mutations, inactivation of the p53 and p16-pRB pathways, active telomerase and MYC expression in pancreatic carcinogenesis and thus recapitulates many features of human PDAC development. 24858378

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis. 24731854

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The striking parallels between the behavior of tumor-derived mutations in disparate regions of the MYC protein reveals that a common molecular process is disrupted by these mutations, implying an active role for these mutations in tumorigenesis and suggesting that different therapeutic strategies may be needed for treatment of lymphomas expressing wild type versus mutant forms of MYC protein. 24998853

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The deubiquitinase USP28 stabilizes oncogenic factors, including c-MYC; however, the contribution of USP28 in tumorigenesis, particularly in the intestine, is unknown. 24960159

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Furthermore, we provide a meta-analysis of TCGA data suggesting that the coordinate regulation of the network is important in MYC driven tumorigenesis. 24857747

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Interestingly, six genes expressed by PICM-19 cells (CDO1, C22orf39, DKK2, ENPEP, GPX6, SRPX2) were completely silenced after MYC-induction in PICM-19-CSCs, suggesting that the absence of these genes may be critical for inducing tumorigenesis. 25717234

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These findings suggest that c-MYC-acetylation is required for the cooperation between p30(II)/c-MYC which could promote proviral replication and contribute to HTLV-1-induced carcinogenesis. 25569455

2015